Multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictors
Pulmonary hypertension is a potentially fatal disease. Despite pharmacological advances in pulmonary hypertension, fatigue remains common in patients with pulmonary hypertension. A convenience sample of 120 participants at an international patient conference completed the Multidimensional Fatigue In...
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2018-03-01
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doaj-76e49f7cb00d411e9f7ec3945e456ed72020-11-24T23:08:53ZengEuropean Respiratory SocietyERJ Open Research2312-05412018-03-014110.1183/23120541.00079-201700079-2017Multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictorsTodd M. Tartavoulle0Aryn C. Karpinski1Andrew Aubin2Benzi M. Kluger3Oliver Distler4Lesley Ann Saketkoo5 School of Nursing, Louisiana State University Health Sciences Center – New Orleans, New Orleans, LA, USA Evaluation and Measurement, School of Foundations, Leadership and Administration, Kent State University, Kent, OH, USA School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA Dept of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA Dept of Rheumatology, University Hospital Zurich, Zurich, Switzerland New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, USA Pulmonary hypertension is a potentially fatal disease. Despite pharmacological advances in pulmonary hypertension, fatigue remains common in patients with pulmonary hypertension. A convenience sample of 120 participants at an international patient conference completed the Multidimensional Fatigue Inventory (MFI)-20 scale. Data on New York Heart Association Functional Class, body mass index, oxygen use and medication type/use were also collected. There was a high prevalence of “severe” to “very severe” fatigue for each dimension: General Fatigue (60%), Physical Fatigue (55.8%), Reduced Activity (41.7%), Reduced Motivation (32.5%) and Mental Fatigue (27.5%). The mean±sd overall MFI-20 score was 58±5.1. Dimensions with the highest averaged levels were General Fatigue (13.40±3.61), Physical Fatigue (13.23±3.67) and Reduced Activity (11.33±4.16). Body mass index correlated with higher fatigue scores. Phosphodiesterase inhibitor plus endothelin receptor antagonist combination negatively predicted General Fatigue, Physical Fatigue, Reduced Motivation and Reduced Activity. Triple therapy was a significant predictor of General Fatigue, Physical Fatigue and Reduced Activity. There were no significant predictors of Mental Fatigue. Multidimensional fatigue is common and severe in patients with pulmonary hypertension. Phosphodiesterase inhibitor plus endothelin receptor antagonist combination resulted in lower scores in most fatigue dimensions. Comprehensive assessment of fatigue should be considered in the clinical care of patients with pulmonary hypertension and clinical research to develop formal interventions that target this disabling symptom.http://openres.ersjournals.com/content/4/1/00079-2017.full |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Todd M. Tartavoulle Aryn C. Karpinski Andrew Aubin Benzi M. Kluger Oliver Distler Lesley Ann Saketkoo |
spellingShingle |
Todd M. Tartavoulle Aryn C. Karpinski Andrew Aubin Benzi M. Kluger Oliver Distler Lesley Ann Saketkoo Multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictors ERJ Open Research |
author_facet |
Todd M. Tartavoulle Aryn C. Karpinski Andrew Aubin Benzi M. Kluger Oliver Distler Lesley Ann Saketkoo |
author_sort |
Todd M. Tartavoulle |
title |
Multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictors |
title_short |
Multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictors |
title_full |
Multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictors |
title_fullStr |
Multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictors |
title_full_unstemmed |
Multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictors |
title_sort |
multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictors |
publisher |
European Respiratory Society |
series |
ERJ Open Research |
issn |
2312-0541 |
publishDate |
2018-03-01 |
description |
Pulmonary hypertension is a potentially fatal disease. Despite pharmacological advances in pulmonary hypertension, fatigue remains common in patients with pulmonary hypertension. A convenience sample of 120 participants at an international patient conference completed the Multidimensional Fatigue Inventory (MFI)-20 scale. Data on New York Heart Association Functional Class, body mass index, oxygen use and medication type/use were also collected. There was a high prevalence of “severe” to “very severe” fatigue for each dimension: General Fatigue (60%), Physical Fatigue (55.8%), Reduced Activity (41.7%), Reduced Motivation (32.5%) and Mental Fatigue (27.5%). The mean±sd overall MFI-20 score was 58±5.1. Dimensions with the highest averaged levels were General Fatigue (13.40±3.61), Physical Fatigue (13.23±3.67) and Reduced Activity (11.33±4.16). Body mass index correlated with higher fatigue scores. Phosphodiesterase inhibitor plus endothelin receptor antagonist combination negatively predicted General Fatigue, Physical Fatigue, Reduced Motivation and Reduced Activity. Triple therapy was a significant predictor of General Fatigue, Physical Fatigue and Reduced Activity. There were no significant predictors of Mental Fatigue. Multidimensional fatigue is common and severe in patients with pulmonary hypertension. Phosphodiesterase inhibitor plus endothelin receptor antagonist combination resulted in lower scores in most fatigue dimensions. Comprehensive assessment of fatigue should be considered in the clinical care of patients with pulmonary hypertension and clinical research to develop formal interventions that target this disabling symptom. |
url |
http://openres.ersjournals.com/content/4/1/00079-2017.full |
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