Mitochondrial DNA sequence variation and neurodegeneration

Mitochondrial DNA sequence variation and neurodegeneration

<p>Abstract</p> <p>Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways. Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Moreover, there is a long hist...

Full description

Bibliographic Details
Main Authors: Mancuso Michelangelo, Filosto Massimiliano, Orsucci Daniele, Siciliano Gabriele
Format: Article
Language:English
Published: BMC 2008-09-01
Series:Human Genomics
Subjects:
mitochondria
mtDNA
mtDNA haplogroups
neurodegenerative disorders
Online Access:http://www.humgenomics.com/content/3/1/71
id doaj-76ebc01ecc694a0cbaeaa823e715f659
record_format Article
spelling doaj-76ebc01ecc694a0cbaeaa823e715f6592020-11-25T00:40:40ZengBMCHuman Genomics1479-73642008-09-0131717810.1186/1479-7364-3-1-71Mitochondrial DNA sequence variation and neurodegenerationMancuso MichelangeloFilosto MassimilianoOrsucci DanieleSiciliano Gabriele<p>Abstract</p> <p>Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways. Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Moreover, there is a long history of investigations on mitochondria aimed at identifying genetic markers relating to ageing and neurodegenerative diseases. In this review, some of the major neurodegenerative disorders are highlighted and the role of mitochondrial haplogroups in the pathogenetic cascade leading to these diseases is discussed.</p> http://www.humgenomics.com/content/3/1/71mitochondriamtDNAmtDNA haplogroupsneurodegenerative disorders
collection DOAJ
language English
format Article
sources DOAJ
author Mancuso Michelangelo
Filosto Massimiliano
Orsucci Daniele
Siciliano Gabriele
spellingShingle Mancuso Michelangelo
Filosto Massimiliano
Orsucci Daniele
Siciliano Gabriele
Mitochondrial DNA sequence variation and neurodegeneration
Human Genomics
mitochondria
mtDNA
mtDNA haplogroups
neurodegenerative disorders
author_facet Mancuso Michelangelo
Filosto Massimiliano
Orsucci Daniele
Siciliano Gabriele
author_sort Mancuso Michelangelo
title Mitochondrial DNA sequence variation and neurodegeneration
title_short Mitochondrial DNA sequence variation and neurodegeneration
title_full Mitochondrial DNA sequence variation and neurodegeneration
title_fullStr Mitochondrial DNA sequence variation and neurodegeneration
title_full_unstemmed Mitochondrial DNA sequence variation and neurodegeneration
title_sort mitochondrial dna sequence variation and neurodegeneration
publisher BMC
series Human Genomics
issn 1479-7364
publishDate 2008-09-01
description <p>Abstract</p> <p>Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways. Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Moreover, there is a long history of investigations on mitochondria aimed at identifying genetic markers relating to ageing and neurodegenerative diseases. In this review, some of the major neurodegenerative disorders are highlighted and the role of mitochondrial haplogroups in the pathogenetic cascade leading to these diseases is discussed.</p>
topic mitochondria
mtDNA
mtDNA haplogroups
neurodegenerative disorders
url http://www.humgenomics.com/content/3/1/71
work_keys_str_mv AT mancusomichelangelo mitochondrialdnasequencevariationandneurodegeneration
AT filostomassimiliano mitochondrialdnasequencevariationandneurodegeneration
AT orsuccidaniele mitochondrialdnasequencevariationandneurodegeneration
AT sicilianogabriele mitochondrialdnasequencevariationandneurodegeneration
_version_ 1725288705785069568

Similar Items