Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype

Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype

Microglia represent the primary resident immune cells of the central nervous system (CNS) and modulate local immune responses. Depending on their physiological functions, microglia can be classified into pro- (M1) and anti-inflammatory (M2) phenotype. Interleukin (IL)-10 is an important modulator of...

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Bibliographic Details
Main Authors: Björn Laffer, Dirk Bauer, Susanne Wasmuth, Martin Busch, Tida Viola Jalilvand, Solon Thanos, Gerd Meyer zu Hörste, Karin Loser, Thomas Langmann, Arnd Heiligenhaus, Maren Kasper
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cytokines
phenotype
interleukin-10
microglia
M1/2 polarization
lipopolysaccharide
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00430/full

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