Identification and characterization of Cardiac Glycosides as senolytic compounds
Senolytic compounds have the ability to eliminate senescent cells from tissues and have been shown to be beneficial in various animal models of age-related diseases. Here the authors show that cardiac glycosides commonly used for heart diseases have senolytic properties in humanized mouse models of...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12888-x |
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doaj-76f6dda146f1406681b8658e9fa1302e |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Francisco Triana-Martínez Pilar Picallos-Rabina Sabela Da Silva-Álvarez Federico Pietrocola Susana Llanos Verónica Rodilla Enrica Soprano Pablo Pedrosa Alba Ferreirós Marta Barradas Fernanda Hernández-González Marta Lalinde Neus Prats Cristina Bernadó Patricia González María Gómez Maria P. Ikonomopoulou Pablo J. Fernández-Marcos Tomás García-Caballero Pablo del Pino Joaquín Arribas Anxo Vidal Miguel González-Barcia Manuel Serrano María I. Loza Eduardo Domínguez Manuel Collado |
| spellingShingle |
Francisco Triana-Martínez Pilar Picallos-Rabina Sabela Da Silva-Álvarez Federico Pietrocola Susana Llanos Verónica Rodilla Enrica Soprano Pablo Pedrosa Alba Ferreirós Marta Barradas Fernanda Hernández-González Marta Lalinde Neus Prats Cristina Bernadó Patricia González María Gómez Maria P. Ikonomopoulou Pablo J. Fernández-Marcos Tomás García-Caballero Pablo del Pino Joaquín Arribas Anxo Vidal Miguel González-Barcia Manuel Serrano María I. Loza Eduardo Domínguez Manuel Collado Identification and characterization of Cardiac Glycosides as senolytic compounds Nature Communications |
| author_facet |
Francisco Triana-Martínez Pilar Picallos-Rabina Sabela Da Silva-Álvarez Federico Pietrocola Susana Llanos Verónica Rodilla Enrica Soprano Pablo Pedrosa Alba Ferreirós Marta Barradas Fernanda Hernández-González Marta Lalinde Neus Prats Cristina Bernadó Patricia González María Gómez Maria P. Ikonomopoulou Pablo J. Fernández-Marcos Tomás García-Caballero Pablo del Pino Joaquín Arribas Anxo Vidal Miguel González-Barcia Manuel Serrano María I. Loza Eduardo Domínguez Manuel Collado |
| author_sort |
Francisco Triana-Martínez |
| title |
Identification and characterization of Cardiac Glycosides as senolytic compounds |
| title_short |
Identification and characterization of Cardiac Glycosides as senolytic compounds |
| title_full |
Identification and characterization of Cardiac Glycosides as senolytic compounds |
| title_fullStr |
Identification and characterization of Cardiac Glycosides as senolytic compounds |
| title_full_unstemmed |
Identification and characterization of Cardiac Glycosides as senolytic compounds |
| title_sort |
identification and characterization of cardiac glycosides as senolytic compounds |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-10-01 |
| description |
Senolytic compounds have the ability to eliminate senescent cells from tissues and have been shown to be beneficial in various animal models of age-related diseases. Here the authors show that cardiac glycosides commonly used for heart diseases have senolytic properties in humanized mouse models of tumorigenesis and lung fibrosis. |
| url |
https://doi.org/10.1038/s41467-019-12888-x |
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doaj-76f6dda146f1406681b8658e9fa1302e2021-05-11T12:38:45ZengNature Publishing GroupNature Communications2041-17232019-10-0110111210.1038/s41467-019-12888-xIdentification and characterization of Cardiac Glycosides as senolytic compoundsFrancisco Triana-Martínez0Pilar Picallos-Rabina1Sabela Da Silva-Álvarez2Federico Pietrocola3Susana Llanos4Verónica Rodilla5Enrica Soprano6Pablo Pedrosa7Alba Ferreirós8Marta Barradas9Fernanda Hernández-González10Marta Lalinde11Neus Prats12Cristina Bernadó13Patricia González14María Gómez15Maria P. Ikonomopoulou16Pablo J. Fernández-Marcos17Tomás García-Caballero18Pablo del Pino19Joaquín Arribas20Anxo Vidal21Miguel González-Barcia22Manuel Serrano23María I. Loza24Eduardo Domínguez25Manuel Collado26Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)DNA Replication Group, Spanish National Cancer Research Centre (CNIO)Preclinical Research Program, Vall d´Hebron Institute of Oncology (VHIO) and CIBERONCCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) and Departamento de Física de Partículas, Universidade de Santiago de CompostelaLaboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)Metabolic Syndrome Group, Madrid Institute for Advanced Studies (IMDEA) in Food, CEI UAM+CSICInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)Preclinical Research Program, Vall d´Hebron Institute of Oncology (VHIO) and CIBERONCInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)Preclinical Research Program, Vall d´Hebron Institute of Oncology (VHIO) and CIBERONCHistopathology Unit, Spanish National Cancer Research Centre (CNIO)Histopathology Unit, Spanish National Cancer Research Centre (CNIO)Translational Venomics Group, Madrid Institute for Advanced Studies (IMDEA) in Food, CEI UAM+CSICMetabolic Syndrome Group, Madrid Institute for Advanced Studies (IMDEA) in Food, CEI UAM+CSICDepartamento de Ciencias Morfológicas, Facultad de Medicina. USC. Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) and Departamento de Física de Partículas, Universidade de Santiago de CompostelaPreclinical Research Program, Vall d´Hebron Institute of Oncology (VHIO) and CIBERONCCiCLOn, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)Servicio de Farmacia, Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)BioFarma, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS)BioFarma, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS)Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)Senolytic compounds have the ability to eliminate senescent cells from tissues and have been shown to be beneficial in various animal models of age-related diseases. Here the authors show that cardiac glycosides commonly used for heart diseases have senolytic properties in humanized mouse models of tumorigenesis and lung fibrosis.https://doi.org/10.1038/s41467-019-12888-x |