Varied Clinico-haematological Presentation of Patients of Megaloblastic Anaemia with Deficiency of Vitamin B12 and Folic Acid in a Tertiary Care Center of Northern India
Introduction: Megaloblastic anaemia is caused by vitamin B12 and/or folic acid deficiency. Clinically megaloblastic anaemia may present as a continuum of asymptomatic metabolic abnormalities ranging to life-threatening clinical syndrome. Patients with megaloblastic anaemia have a risk of develop...
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doaj-76f75879ff1744519e6918595d822aea2020-11-25T03:02:18ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-12-011112EC06EC0910.7860/JCDR/2017/30253.10937Varied Clinico-haematological Presentation of Patients of Megaloblastic Anaemia with Deficiency of Vitamin B12 and Folic Acid in a Tertiary Care Center of Northern IndiaAmreen Brown0Nishi Tandon1Syed Riaz Mehdi2Zeba Siddiqui3Junior Resident, Department of Pathology, Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.Associate Professor, Department of Pathology, Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.Professor and Head, Department of Pathology, Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.Associate Professor, Department of Medicine, Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.Introduction: Megaloblastic anaemia is caused by vitamin B12 and/or folic acid deficiency. Clinically megaloblastic anaemia may present as a continuum of asymptomatic metabolic abnormalities ranging to life-threatening clinical syndrome. Patients with megaloblastic anaemia have a risk of developing many complications. Aim: The aim of present study was to evaluate the varied clinicohaematological presentation of patients of megaloblastic anaemia associated with deficiency of vitamin B12 and folic acid. Materials and Methods: This cross-sectional study was carried out in the Department of Pathology, Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India, over a period of 18 months. We studied 90 cases which were grouped as follows: Group A: no deficiency; Group B: vitamin B12 deficiency; Group C: folic acid deficiency; Group D: combined deficiency. Complete blood count was done using Sysmex XS800i. Vitamin B12 and folic acid assay was done using Enzyme Linked Immunosorbent Assay (ELISA). Bone marrow aspiration was also done. Results: Out of 90 patients, maximum (n=42; 46.7%) had vitamin B12 deficiency. In all the four groups, weakness and fatigue were the most common complaints. All the cases had pallor. Icterus, tingling, numbness and murmurs were relatively rare. All the fourteen cases in which bone marrow examination was carried out had erythroid hyperplasia and megaloblastic reaction. Conclusion: On the basis of above findings, it was concluded that there is a significant difference in the clinical presentation of patients of megaloblastic anaemia with vitamin B12 and folic acid deficiency. However, not very significant difference has been noticed in the haematological parameters. Thus, clinical and haematological profile both should be thoroughly assessed to differentiate between vitamin B12 and folic acid deficiency.https://jcdr.net/articles/PDF/10937/30253_CE(RA1)_F(T)_PF1(AA_GG)_PFA(MJ_AP)_PFA2(MJ_AP)_PB(MJ_GG).pdfbone marrowfolic acid deficiency macrocytosisvitamin b12 deficiency |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amreen Brown Nishi Tandon Syed Riaz Mehdi Zeba Siddiqui |
spellingShingle |
Amreen Brown Nishi Tandon Syed Riaz Mehdi Zeba Siddiqui Varied Clinico-haematological Presentation of Patients of Megaloblastic Anaemia with Deficiency of Vitamin B12 and Folic Acid in a Tertiary Care Center of Northern India Journal of Clinical and Diagnostic Research bone marrow folic acid deficiency macrocytosis vitamin b12 deficiency |
author_facet |
Amreen Brown Nishi Tandon Syed Riaz Mehdi Zeba Siddiqui |
author_sort |
Amreen Brown |
title |
Varied Clinico-haematological Presentation of Patients of Megaloblastic Anaemia with Deficiency of Vitamin B12 and Folic Acid in a Tertiary Care Center of Northern India |
title_short |
Varied Clinico-haematological Presentation of Patients of Megaloblastic Anaemia with Deficiency of Vitamin B12 and Folic Acid in a Tertiary Care Center of Northern India |
title_full |
Varied Clinico-haematological Presentation of Patients of Megaloblastic Anaemia with Deficiency of Vitamin B12 and Folic Acid in a Tertiary Care Center of Northern India |
title_fullStr |
Varied Clinico-haematological Presentation of Patients of Megaloblastic Anaemia with Deficiency of Vitamin B12 and Folic Acid in a Tertiary Care Center of Northern India |
title_full_unstemmed |
Varied Clinico-haematological Presentation of Patients of Megaloblastic Anaemia with Deficiency of Vitamin B12 and Folic Acid in a Tertiary Care Center of Northern India |
title_sort |
varied clinico-haematological presentation of patients of megaloblastic anaemia with deficiency of vitamin b12 and folic acid in a tertiary care center of northern india |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2017-12-01 |
description |
Introduction: Megaloblastic anaemia is caused by vitamin B12
and/or folic acid deficiency. Clinically megaloblastic anaemia
may present as a continuum of asymptomatic metabolic
abnormalities ranging to life-threatening clinical syndrome.
Patients with megaloblastic anaemia have a risk of developing
many complications.
Aim: The aim of present study was to evaluate the varied clinicohaematological presentation of patients of megaloblastic anaemia
associated with deficiency of vitamin B12 and folic acid.
Materials and Methods: This cross-sectional study was carried
out in the Department of Pathology, Era’s Lucknow Medical
College and Hospital, Lucknow, Uttar Pradesh, India, over a
period of 18 months. We studied 90 cases which were grouped
as follows: Group A: no deficiency; Group B: vitamin B12
deficiency; Group C: folic acid deficiency; Group D: combined
deficiency. Complete blood count was done using Sysmex XS800i. Vitamin B12 and folic acid assay was done using Enzyme
Linked Immunosorbent Assay (ELISA). Bone marrow aspiration
was also done.
Results: Out of 90 patients, maximum (n=42; 46.7%) had
vitamin B12 deficiency. In all the four groups, weakness and
fatigue were the most common complaints. All the cases had
pallor. Icterus, tingling, numbness and murmurs were relatively
rare. All the fourteen cases in which bone marrow examination
was carried out had erythroid hyperplasia and megaloblastic
reaction.
Conclusion: On the basis of above findings, it was concluded
that there is a significant difference in the clinical presentation
of patients of megaloblastic anaemia with vitamin B12 and folic
acid deficiency. However, not very significant difference has
been noticed in the haematological parameters. Thus, clinical
and haematological profile both should be thoroughly assessed
to differentiate between vitamin B12 and folic acid deficiency. |
topic |
bone marrow folic acid deficiency macrocytosis vitamin b12 deficiency |
url |
https://jcdr.net/articles/PDF/10937/30253_CE(RA1)_F(T)_PF1(AA_GG)_PFA(MJ_AP)_PFA2(MJ_AP)_PB(MJ_GG).pdf |
work_keys_str_mv |
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1724690310938755072 |