NAADP: From Discovery to Mechanism
Nicotinic acid adenine dinucleotide 2’-phosphate (NAADP) is a naturally occurring nucleotide that has been shown to be involved in the release of Ca2+ from intracellular stores in a wide variety of cell types, tissues and organisms. Current evidence suggests that NAADP may function as a trigger to i...
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.703326/full |
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doaj-76fa38e63779414ba0fcab6ae46e973b2021-09-07T05:29:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-09-011210.3389/fimmu.2021.703326703326NAADP: From Discovery to MechanismTimothy F. Walseth0Andreas H. Guse1Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, United StatesThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyNicotinic acid adenine dinucleotide 2’-phosphate (NAADP) is a naturally occurring nucleotide that has been shown to be involved in the release of Ca2+ from intracellular stores in a wide variety of cell types, tissues and organisms. Current evidence suggests that NAADP may function as a trigger to initiate a Ca2+ signal that is then amplified by other Ca2+ release mechanisms. A fundamental question that remains unanswered is the identity of the NAADP receptor. Our recent studies have identified HN1L/JPT2 as a high affinity NAADP binding protein that is essential for the modulation of Ca2+ channels.https://www.frontiersin.org/articles/10.3389/fimmu.2021.703326/fullNAADPHN1L/JPT2ryanodine receptortwo-pore channelcalcium signaling |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Timothy F. Walseth Andreas H. Guse |
| spellingShingle |
Timothy F. Walseth Andreas H. Guse NAADP: From Discovery to Mechanism Frontiers in Immunology NAADP HN1L/JPT2 ryanodine receptor two-pore channel calcium signaling |
| author_facet |
Timothy F. Walseth Andreas H. Guse |
| author_sort |
Timothy F. Walseth |
| title |
NAADP: From Discovery to Mechanism |
| title_short |
NAADP: From Discovery to Mechanism |
| title_full |
NAADP: From Discovery to Mechanism |
| title_fullStr |
NAADP: From Discovery to Mechanism |
| title_full_unstemmed |
NAADP: From Discovery to Mechanism |
| title_sort |
naadp: from discovery to mechanism |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Immunology |
| issn |
1664-3224 |
| publishDate |
2021-09-01 |
| description |
Nicotinic acid adenine dinucleotide 2’-phosphate (NAADP) is a naturally occurring nucleotide that has been shown to be involved in the release of Ca2+ from intracellular stores in a wide variety of cell types, tissues and organisms. Current evidence suggests that NAADP may function as a trigger to initiate a Ca2+ signal that is then amplified by other Ca2+ release mechanisms. A fundamental question that remains unanswered is the identity of the NAADP receptor. Our recent studies have identified HN1L/JPT2 as a high affinity NAADP binding protein that is essential for the modulation of Ca2+ channels. |
| topic |
NAADP HN1L/JPT2 ryanodine receptor two-pore channel calcium signaling |
| url |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.703326/full |
| work_keys_str_mv |
AT timothyfwalseth naadpfromdiscoverytomechanism AT andreashguse naadpfromdiscoverytomechanism |
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1717764802790555648 |