Survey to identify Mycobacterium leprae-infected household contacts of patients from prevalent regions of leprosy in Colombia
Leprosy in Colombia is in the post-elimination phase; nevertheless, there are regions of this country where the incidence is still around 3-4/100,000. Early detection of leprosy patients is a priority for achieving control and elimination of leprosy; however, the clinical exam is not very sensitive...
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Instituto Oswaldo Cruz, Ministério da Saúde
2008-06-01
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000400003 |
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doaj-76fda2f42b294229a62e486f0a7a8fc02020-11-25T00:49:59ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.0074-02761678-80602008-06-01103433233610.1590/S0074-02762008000400003Survey to identify Mycobacterium leprae-infected household contacts of patients from prevalent regions of leprosy in ColombiaN Cardona-CastroJC Beltrán-AlzateR Manrique-HernándezLeprosy in Colombia is in the post-elimination phase; nevertheless, there are regions of this country where the incidence is still around 3-4/100,000. Early detection of leprosy patients is a priority for achieving control and elimination of leprosy; however, the clinical exam is not very sensitive and thus, the majority of patients are diagnosed only when they demonstrate lesions, and damage to the nerves and skin has already occurred. The goal of the present study was to identify Mycobacterium leprae infection and immune responses in household contacts (HHC) of leprosy patients from three prevalent regions of Colombia. Clinical examination, the Mitsuda test, evaluation of IgM anti-PGL-I in the serum, the bacillar index (BI), and polymerase chain reaction (PCR) from nasal swabs (NS) were performed for 402 HHC of 104 leprosy patients during a cross-sectional survey. Positive titers for IgM anti-PGL1 were found for 54 HHC, and PCR-positive NS for 22. The Mitsuda reaction was negative for 38 HHC, although three were positive for IgM anti-PGL-1 titers. The data document that leprosy transmission among HHC is still occurring in a non-endemic country.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000400003leprosyMycobacterium lepraehousehold contactsIgM anti PGL-1Mitsuda reaction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
N Cardona-Castro JC Beltrán-Alzate R Manrique-Hernández |
spellingShingle |
N Cardona-Castro JC Beltrán-Alzate R Manrique-Hernández Survey to identify Mycobacterium leprae-infected household contacts of patients from prevalent regions of leprosy in Colombia Memórias do Instituto Oswaldo Cruz. leprosy Mycobacterium leprae household contacts IgM anti PGL-1 Mitsuda reaction |
author_facet |
N Cardona-Castro JC Beltrán-Alzate R Manrique-Hernández |
author_sort |
N Cardona-Castro |
title |
Survey to identify Mycobacterium leprae-infected household contacts of patients from prevalent regions of leprosy in Colombia |
title_short |
Survey to identify Mycobacterium leprae-infected household contacts of patients from prevalent regions of leprosy in Colombia |
title_full |
Survey to identify Mycobacterium leprae-infected household contacts of patients from prevalent regions of leprosy in Colombia |
title_fullStr |
Survey to identify Mycobacterium leprae-infected household contacts of patients from prevalent regions of leprosy in Colombia |
title_full_unstemmed |
Survey to identify Mycobacterium leprae-infected household contacts of patients from prevalent regions of leprosy in Colombia |
title_sort |
survey to identify mycobacterium leprae-infected household contacts of patients from prevalent regions of leprosy in colombia |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
series |
Memórias do Instituto Oswaldo Cruz. |
issn |
0074-0276 1678-8060 |
publishDate |
2008-06-01 |
description |
Leprosy in Colombia is in the post-elimination phase; nevertheless, there are regions of this country where the incidence is still around 3-4/100,000. Early detection of leprosy patients is a priority for achieving control and elimination of leprosy; however, the clinical exam is not very sensitive and thus, the majority of patients are diagnosed only when they demonstrate lesions, and damage to the nerves and skin has already occurred. The goal of the present study was to identify Mycobacterium leprae infection and immune responses in household contacts (HHC) of leprosy patients from three prevalent regions of Colombia. Clinical examination, the Mitsuda test, evaluation of IgM anti-PGL-I in the serum, the bacillar index (BI), and polymerase chain reaction (PCR) from nasal swabs (NS) were performed for 402 HHC of 104 leprosy patients during a cross-sectional survey. Positive titers for IgM anti-PGL1 were found for 54 HHC, and PCR-positive NS for 22. The Mitsuda reaction was negative for 38 HHC, although three were positive for IgM anti-PGL-1 titers. The data document that leprosy transmission among HHC is still occurring in a non-endemic country. |
topic |
leprosy Mycobacterium leprae household contacts IgM anti PGL-1 Mitsuda reaction |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000400003 |
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