Tobacco exposure inhibits SPLUNC1-dependent antimicrobial activity

Tobacco exposure inhibits SPLUNC1-dependent antimicrobial activity

Abstract Background Tobacco smoke exposure impairs the lung’s innate immune response, leading to an increased risk of chronic infections. SPLUNC1 is a secreted, multifunctional innate defense protein that has antimicrobial activity against Gram negative organisms. We hypothesize that tobacco smoke-i...

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Bibliographic Details
Main Authors: Patrick J. Moore, Juliana Sesma, Neil E. Alexis, Robert Tarran
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Respiratory Research
Subjects:
Sputum
COPD
Little cigars
BPIFA1
Online Access:http://link.springer.com/article/10.1186/s12931-019-1066-2

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