Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats

Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats

Abstract Background Deletion or mutations of SHANK3 lead to Phelan–McDermid syndrome and monogenic forms of autism spectrum disorder (ASD). SHANK3 encodes its eponymous scaffolding protein at excitatory glutamatergic synapses. Altered morphology of dendrites and spines in the hippocampus, cerebellum...

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Bibliographic Details
Main Authors: Sarah Jacot-Descombes, Neha U. Keshav, Dara L. Dickstein, Bridget Wicinski, William G. M. Janssen, Liam L. Hiester, Edward K. Sarfo, Tahia Warda, Matthew M. Fam, Hala Harony-Nicolas, Joseph D. Buxbaum, Patrick R. Hof, Merina Varghese
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Molecular Autism
Subjects:
Autism spectrum disorder
Phelan–McDermid syndrome
Synapse morphology
Electron microscopy
Online Access:http://link.springer.com/article/10.1186/s13229-020-00393-8

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http://link.springer.com/article/10.1186/s13229-020-00393-8

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