Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats
Abstract Background Deletion or mutations of SHANK3 lead to Phelan–McDermid syndrome and monogenic forms of autism spectrum disorder (ASD). SHANK3 encodes its eponymous scaffolding protein at excitatory glutamatergic synapses. Altered morphology of dendrites and spines in the hippocampus, cerebellum...
Main Authors: | Sarah Jacot-Descombes, Neha U. Keshav, Dara L. Dickstein, Bridget Wicinski, William G. M. Janssen, Liam L. Hiester, Edward K. Sarfo, Tahia Warda, Matthew M. Fam, Hala Harony-Nicolas, Joseph D. Buxbaum, Patrick R. Hof, Merina Varghese |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-11-01
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Series: | Molecular Autism |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13229-020-00393-8 |
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