Tumor Necrosis Factor Alpha Signaling and Organogenesis
Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication. TNF-α and its receptors are ubiquitously expressed in developing organs and they regulate the survival, p...
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doaj-77006f90947d41ce9b855cac604bba462021-07-30T07:05:13ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-07-01910.3389/fcell.2021.727075727075Tumor Necrosis Factor Alpha Signaling and OrganogenesisKai You0Hui Gu1Zhengwei Yuan2Xuewen Xu3Xuewen Xu4Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, ChinaKey Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, ChinaKey Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, ChinaKey Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Urology, Shengjing Hospital of China Medical University, Shenyang, ChinaTumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication. TNF-α and its receptors are ubiquitously expressed in developing organs and they regulate the survival, proliferation, and apoptosis of embryonic stem cells (ESCs) and progenitor cells. TNF-α is an important inflammatory factor that also regulates the inflammatory response during organogenesis, and its cytotoxic effects can interfere with normal developmental processes, even leading to the onset of diseases. This review summarizes the various roles of TNF-α in organogenesis in terms of its secreting pattern, concentration-dependent activities, and interactions with other signaling pathways. We also explored new potential functions of TNF-α.https://www.frontiersin.org/articles/10.3389/fcell.2021.727075/fulltumor necrosis factor alphacell communicationdevelopmentmorphogenesisorganogenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kai You Hui Gu Zhengwei Yuan Xuewen Xu Xuewen Xu |
spellingShingle |
Kai You Hui Gu Zhengwei Yuan Xuewen Xu Xuewen Xu Tumor Necrosis Factor Alpha Signaling and Organogenesis Frontiers in Cell and Developmental Biology tumor necrosis factor alpha cell communication development morphogenesis organogenesis |
author_facet |
Kai You Hui Gu Zhengwei Yuan Xuewen Xu Xuewen Xu |
author_sort |
Kai You |
title |
Tumor Necrosis Factor Alpha Signaling and Organogenesis |
title_short |
Tumor Necrosis Factor Alpha Signaling and Organogenesis |
title_full |
Tumor Necrosis Factor Alpha Signaling and Organogenesis |
title_fullStr |
Tumor Necrosis Factor Alpha Signaling and Organogenesis |
title_full_unstemmed |
Tumor Necrosis Factor Alpha Signaling and Organogenesis |
title_sort |
tumor necrosis factor alpha signaling and organogenesis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2021-07-01 |
description |
Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication. TNF-α and its receptors are ubiquitously expressed in developing organs and they regulate the survival, proliferation, and apoptosis of embryonic stem cells (ESCs) and progenitor cells. TNF-α is an important inflammatory factor that also regulates the inflammatory response during organogenesis, and its cytotoxic effects can interfere with normal developmental processes, even leading to the onset of diseases. This review summarizes the various roles of TNF-α in organogenesis in terms of its secreting pattern, concentration-dependent activities, and interactions with other signaling pathways. We also explored new potential functions of TNF-α. |
topic |
tumor necrosis factor alpha cell communication development morphogenesis organogenesis |
url |
https://www.frontiersin.org/articles/10.3389/fcell.2021.727075/full |
work_keys_str_mv |
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