The Yin and Yang of VEGF and PEDF: Multifaceted Neurotrophic Factors and Their Potential in the Treatment of Parkinson’s Disease

Over the last few decades, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have ext...

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Main Authors:	Scott J. Sherman, Robert T. Gonzalez, Torsten Falk
Format:	Article
Language:	English
Published:	MDPI AG 2010-08-01
Series:	International Journal of Molecular Sciences
Subjects:	neurodegeneration VEGF-A VEGF-B PEDF VEGFR1 VEGFR2 PEDF-R
Online Access:	http://www.mdpi.com/1422-0067/11/8/2875/

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spelling	doaj-7701d6e2461e4ceba6b611166659cf652020-11-24T22:20:19ZengMDPI AGInternational Journal of Molecular Sciences1422-00672010-08-011182875290010.3390/ijms11082875The Yin and Yang of VEGF and PEDF: Multifaceted Neurotrophic Factors and Their Potential in the Treatment of Parkinson’s DiseaseScott J. ShermanRobert T. GonzalezTorsten FalkOver the last few decades, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have extensive crosstalk, and have been best studied for their effects in cardiology and cancer biology. Recent work with the two factors indicates that the activity of one growth factor is often directly related to the action of the other. Their respective neuroprotective effects, in particular, raise important questions regarding the treatment of neurodegenerative disorders, including Parkinson’s disease. http://www.mdpi.com/1422-0067/11/8/2875/neurodegenerationVEGF-AVEGF-BPEDFVEGFR1VEGFR2PEDF-R
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Scott J. Sherman Robert T. Gonzalez Torsten Falk
spellingShingle	Scott J. Sherman Robert T. Gonzalez Torsten Falk The Yin and Yang of VEGF and PEDF: Multifaceted Neurotrophic Factors and Their Potential in the Treatment of Parkinson’s Disease International Journal of Molecular Sciences neurodegeneration VEGF-A VEGF-B PEDF VEGFR1 VEGFR2 PEDF-R
author_facet	Scott J. Sherman Robert T. Gonzalez Torsten Falk
author_sort	Scott J. Sherman
title	The Yin and Yang of VEGF and PEDF: Multifaceted Neurotrophic Factors and Their Potential in the Treatment of Parkinson’s Disease
title_short	The Yin and Yang of VEGF and PEDF: Multifaceted Neurotrophic Factors and Their Potential in the Treatment of Parkinson’s Disease
title_full	The Yin and Yang of VEGF and PEDF: Multifaceted Neurotrophic Factors and Their Potential in the Treatment of Parkinson’s Disease
title_fullStr	The Yin and Yang of VEGF and PEDF: Multifaceted Neurotrophic Factors and Their Potential in the Treatment of Parkinson’s Disease
title_full_unstemmed	The Yin and Yang of VEGF and PEDF: Multifaceted Neurotrophic Factors and Their Potential in the Treatment of Parkinson’s Disease
title_sort	yin and yang of vegf and pedf: multifaceted neurotrophic factors and their potential in the treatment of parkinson’s disease
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2010-08-01
description	Over the last few decades, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have extensive crosstalk, and have been best studied for their effects in cardiology and cancer biology. Recent work with the two factors indicates that the activity of one growth factor is often directly related to the action of the other. Their respective neuroprotective effects, in particular, raise important questions regarding the treatment of neurodegenerative disorders, including Parkinson’s disease.
topic	neurodegeneration VEGF-A VEGF-B PEDF VEGFR1 VEGFR2 PEDF-R
url	http://www.mdpi.com/1422-0067/11/8/2875/
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The Yin and Yang of VEGF and PEDF: Multifaceted Neurotrophic Factors and Their Potential in the Treatment of Parkinson’s Disease

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