Risk of pancreatic cancer in patients undergoing surgery for chronic pancreatitis
Abstract Background Chronic pancreatitis (CP) is considered to be a risk factor for pancreatic cancer. A retrospective study was conducted to evaluate the incidence of pancreatic cancer after surgery for CP and to determine the risk factors. Methods The patients who underwent surgery for histologica...
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doaj-7706b5000bb245f9b3d232deaffec6b42020-11-25T03:48:26ZengBMCBMC Surgery1471-24822019-07-011911910.1186/s12893-019-0537-1Risk of pancreatic cancer in patients undergoing surgery for chronic pancreatitisZhenjiang Zheng0Yonghua Chen1Chunlu Tan2Nengwen Ke3Binqing Du4Xubao Liu5Department of Pancreatic Surgery, West China Hospital, Sichuan UniversityDepartment of Pancreatic Surgery, West China Hospital, Sichuan UniversityDepartment of Pancreatic Surgery, West China Hospital, Sichuan UniversityDepartment of Pancreatic Surgery, West China Hospital, Sichuan UniversityDepartment of Pancreatic Surgery, West China Hospital, Sichuan UniversityDepartment of Pancreatic Surgery, West China Hospital, Sichuan UniversityAbstract Background Chronic pancreatitis (CP) is considered to be a risk factor for pancreatic cancer. A retrospective study was conducted to evaluate the incidence of pancreatic cancer after surgery for CP and to determine the risk factors. Methods The patients who underwent surgery for histologically documented CP between January 2009 and December 2017 were reviewed. The baseline characteristics, operative data, postoperative complications, and follow-up information were analysed. We calculated standardized incidence ratio on the base of the incidence of pancreatic cancer in the standard population in China. The risk factor for pancreatic cancer was assessed using Cox regression. Results Among 650 patients, pancreatic cancer was detected in 12 patients (1.8%) after a median follow-up of 4.4 years. The standardized incidence ratio of pancreatic cancer was 68.12 (95% CI, 35.20–118.99). Two independent risk factors for the development of pancreatic cancer in patients with chronic pancreatitis after surgery were identified: time interval to surgery [HR 1.005, 95% CI (1.002–1.008), P = 0.002] and de novo endocrine insufficiency [HR 10.672, 95% CI (2.567–44.372), P = 0.001]. Conclusions Patients who require surgery for CP are at a very high risk of developing pancreatic cancer. Early surgical intervention plays a protective role in the development of pancreatic cancer from CP. A high index of suspicion for pancreatic cancer should be maintained in CP patients with de novo postoperative diabetes after surgery.http://link.springer.com/article/10.1186/s12893-019-0537-1Chronic pancreatitisPancreatic cancerSurgeryRisk factor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhenjiang Zheng Yonghua Chen Chunlu Tan Nengwen Ke Binqing Du Xubao Liu |
spellingShingle |
Zhenjiang Zheng Yonghua Chen Chunlu Tan Nengwen Ke Binqing Du Xubao Liu Risk of pancreatic cancer in patients undergoing surgery for chronic pancreatitis BMC Surgery Chronic pancreatitis Pancreatic cancer Surgery Risk factor |
author_facet |
Zhenjiang Zheng Yonghua Chen Chunlu Tan Nengwen Ke Binqing Du Xubao Liu |
author_sort |
Zhenjiang Zheng |
title |
Risk of pancreatic cancer in patients undergoing surgery for chronic pancreatitis |
title_short |
Risk of pancreatic cancer in patients undergoing surgery for chronic pancreatitis |
title_full |
Risk of pancreatic cancer in patients undergoing surgery for chronic pancreatitis |
title_fullStr |
Risk of pancreatic cancer in patients undergoing surgery for chronic pancreatitis |
title_full_unstemmed |
Risk of pancreatic cancer in patients undergoing surgery for chronic pancreatitis |
title_sort |
risk of pancreatic cancer in patients undergoing surgery for chronic pancreatitis |
publisher |
BMC |
series |
BMC Surgery |
issn |
1471-2482 |
publishDate |
2019-07-01 |
description |
Abstract Background Chronic pancreatitis (CP) is considered to be a risk factor for pancreatic cancer. A retrospective study was conducted to evaluate the incidence of pancreatic cancer after surgery for CP and to determine the risk factors. Methods The patients who underwent surgery for histologically documented CP between January 2009 and December 2017 were reviewed. The baseline characteristics, operative data, postoperative complications, and follow-up information were analysed. We calculated standardized incidence ratio on the base of the incidence of pancreatic cancer in the standard population in China. The risk factor for pancreatic cancer was assessed using Cox regression. Results Among 650 patients, pancreatic cancer was detected in 12 patients (1.8%) after a median follow-up of 4.4 years. The standardized incidence ratio of pancreatic cancer was 68.12 (95% CI, 35.20–118.99). Two independent risk factors for the development of pancreatic cancer in patients with chronic pancreatitis after surgery were identified: time interval to surgery [HR 1.005, 95% CI (1.002–1.008), P = 0.002] and de novo endocrine insufficiency [HR 10.672, 95% CI (2.567–44.372), P = 0.001]. Conclusions Patients who require surgery for CP are at a very high risk of developing pancreatic cancer. Early surgical intervention plays a protective role in the development of pancreatic cancer from CP. A high index of suspicion for pancreatic cancer should be maintained in CP patients with de novo postoperative diabetes after surgery. |
topic |
Chronic pancreatitis Pancreatic cancer Surgery Risk factor |
url |
http://link.springer.com/article/10.1186/s12893-019-0537-1 |
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