Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells

Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells

The association between intratumoral cholesteryl ester (CE) and tumor progression has been reported previously. The objective of our study was to investigate a causal effect of CE on mammary tumor progression. Using MMTV-PyMT (MMTV-polyoma virus middle T) transgenic mice and breast tumor cell MCF-7,...

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Bibliographic Details
Main Authors: Lengyun Wei, Xuyang Lu, Shengmei Weng, Shenglong Zhu, Yongquan Chen
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomolecules
Subjects:
breast cancer
cholesteryl ester
SOAT1
avasimibe
Online Access:https://www.mdpi.com/2218-273X/11/6/853

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