Effect of Aerobic Training and L-Carnitine Consumption on Some Oxidative Stress Factors in Diabetic Rat kidney

• Main Authors: A Fakourian, H Matinhomaee, MA Azarbayjani, P Farzanegi
• Format: Article
• Language: fas
• Published: Yasuj University Of Medical Sciences 2019-07-01
• Series: Armaghane Danesh Bimonthly Journal
• Subjects: Aerobic training; L-carnitine; Diabetes; SOD; GPX; MDA; Kidney
• Online Access: http://armaghanj.yums.ac.ir/article-1-2385-en.html

Abstract                 Background & aim: The use of non-enzymatic antioxidants in food supplements and proper exercise can have a positive effect on decreasing oxidative stress by free radical hunting. The purpose of this study was to investigate the effect of aerobic training and consumption of l-carnitine on some of the oxidative stress factors in diabetic kidney.   Methods: In the present experimental study, 45 male Wistar rats(200-300 gr) were randomly divided into six groups: 1) sham group, 2) healthy control group 3) diabetic control group, 4) diabetic group receiving l-carnitine, 5) diabetic group of aerobic training, 6) diabetic group of aerobic training and receiving l-carnitine. Rats were diabetic peritoneal injected with nicotinic amide and a single dose of STZ of 55 mg / kg body weight. Rats in the L-carnitine group received daily of 100 mg of l-carnitine orally. The aerobic exercise protocol included five sessions per week on the treadmill. Data were analyzed by two way ANOVA and Tukey post hoc test at P <0.05.   Results: Six weeks of aerobic exercise, supplementation of  l-carnitine and combined intervention of aerobic exercise and supplementation of l-carnitine do not have a significant effect on MDA and SOD  factors of kidney  tissue in diabetic rats(p>0.05). However, six weeks of aerobic exercise had a significant effect on GPX factor in kidney tissue in diabetic rats (p=0.003). Moreover, supplementation   and combined intervention of aerobic exercise and supplementation of l-carnitine did not have a significant effect on GPX factor of kidney tissue in diabetic rats (p>0.05)   Conclusion: L-carnitine supplementation intake with regular exercise can have beneficial effects on the body, antioxidant defense system and decreases oxidative stress in rats with type 2 diabetes.