A possible origin population of pathogenic intestinal nematodes, Strongyloides stercoralis, unveiled by molecular phylogeny

Abstract Humans and dogs are the two major hosts of Strongyloides stercoralis, an intestinal parasitic nematode. To better understand the phylogenetic relationships among S. stercoralis isolates infecting humans and dogs and to assess the zoonotic potential of this parasite, we analyzed mitochondria...

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Main Authors: Eiji Nagayasu, Myo Pa Pa Thet Hnin Htwe Aung, Thanaporn Hortiwakul, Akina Hino, Teruhisa Tanaka, Miwa Higashiarakawa, Alex Olia, Tomoyo Taniguchi, Soe Moe Thu Win, Isao Ohashi, Emmanuel Igwaro Odongo-Aginya, Khin Myo Aye, Mon Mon, Kyu Kyu Win, Kei Ota, Yukari Torisu, Siripen Panthuwong, Eisaku Kimura, Nirianne M. Q. Palacpac, Taisei Kikuchi, Tetsuo Hirata, Shidow Torisu, Hajime Hisaeda, Toshihiro Horii, Jiro Fujita, Wah Win Htike, Haruhiko Maruyama
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05049-x
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author Eiji Nagayasu
Myo Pa Pa Thet Hnin Htwe Aung
Thanaporn Hortiwakul
Akina Hino
Teruhisa Tanaka
Miwa Higashiarakawa
Alex Olia
Tomoyo Taniguchi
Soe Moe Thu Win
Isao Ohashi
Emmanuel Igwaro Odongo-Aginya
Khin Myo Aye
Mon Mon
Kyu Kyu Win
Kei Ota
Yukari Torisu
Siripen Panthuwong
Eisaku Kimura
Nirianne M. Q. Palacpac
Taisei Kikuchi
Tetsuo Hirata
Shidow Torisu
Hajime Hisaeda
Toshihiro Horii
Jiro Fujita
Wah Win Htike
Haruhiko Maruyama
spellingShingle Eiji Nagayasu
Myo Pa Pa Thet Hnin Htwe Aung
Thanaporn Hortiwakul
Akina Hino
Teruhisa Tanaka
Miwa Higashiarakawa
Alex Olia
Tomoyo Taniguchi
Soe Moe Thu Win
Isao Ohashi
Emmanuel Igwaro Odongo-Aginya
Khin Myo Aye
Mon Mon
Kyu Kyu Win
Kei Ota
Yukari Torisu
Siripen Panthuwong
Eisaku Kimura
Nirianne M. Q. Palacpac
Taisei Kikuchi
Tetsuo Hirata
Shidow Torisu
Hajime Hisaeda
Toshihiro Horii
Jiro Fujita
Wah Win Htike
Haruhiko Maruyama
A possible origin population of pathogenic intestinal nematodes, Strongyloides stercoralis, unveiled by molecular phylogeny
Scientific Reports
author_facet Eiji Nagayasu
Myo Pa Pa Thet Hnin Htwe Aung
Thanaporn Hortiwakul
Akina Hino
Teruhisa Tanaka
Miwa Higashiarakawa
Alex Olia
Tomoyo Taniguchi
Soe Moe Thu Win
Isao Ohashi
Emmanuel Igwaro Odongo-Aginya
Khin Myo Aye
Mon Mon
Kyu Kyu Win
Kei Ota
Yukari Torisu
Siripen Panthuwong
Eisaku Kimura
Nirianne M. Q. Palacpac
Taisei Kikuchi
Tetsuo Hirata
Shidow Torisu
Hajime Hisaeda
Toshihiro Horii
Jiro Fujita
Wah Win Htike
Haruhiko Maruyama
author_sort Eiji Nagayasu
title A possible origin population of pathogenic intestinal nematodes, Strongyloides stercoralis, unveiled by molecular phylogeny
title_short A possible origin population of pathogenic intestinal nematodes, Strongyloides stercoralis, unveiled by molecular phylogeny
title_full A possible origin population of pathogenic intestinal nematodes, Strongyloides stercoralis, unveiled by molecular phylogeny
title_fullStr A possible origin population of pathogenic intestinal nematodes, Strongyloides stercoralis, unveiled by molecular phylogeny
title_full_unstemmed A possible origin population of pathogenic intestinal nematodes, Strongyloides stercoralis, unveiled by molecular phylogeny
title_sort possible origin population of pathogenic intestinal nematodes, strongyloides stercoralis, unveiled by molecular phylogeny
publisher Nature Publishing Group
series Scientific Reports
issn 2045-2322
publishDate 2017-07-01
description Abstract Humans and dogs are the two major hosts of Strongyloides stercoralis, an intestinal parasitic nematode. To better understand the phylogenetic relationships among S. stercoralis isolates infecting humans and dogs and to assess the zoonotic potential of this parasite, we analyzed mitochondrial Cox1, nuclear 18S rDNA, 28S rDNA, and a major sperm protein domain-containing protein genes. Overall, our analyses indicated the presence of two distinct lineages of S. stercoralis (referred to as type A and type B). While type A parasites were isolated both from humans and dogs in different countries, type B parasites were found exclusively in dogs, indicating that the type B has not adapted to infect humans. These epidemiological data, together with the close phylogenetic relationship of S. stercoralis with S. procyonis, a Strongyloides parasite of raccoons, possibly indicates that S. stercoralis originally evolved as a canid parasite, and later spread into humans. The inability to infect humans might be an ancestral character of this species and the type B might be surmised to be an origin population from which human-infecting strains are derived.
url https://doi.org/10.1038/s41598-017-05049-x
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spelling doaj-7711f908a9c24136b71085a7c38b53692020-12-08T02:45:25ZengNature Publishing GroupScientific Reports2045-23222017-07-017111310.1038/s41598-017-05049-xA possible origin population of pathogenic intestinal nematodes, Strongyloides stercoralis, unveiled by molecular phylogenyEiji Nagayasu0Myo Pa Pa Thet Hnin Htwe Aung1Thanaporn Hortiwakul2Akina Hino3Teruhisa Tanaka4Miwa Higashiarakawa5Alex Olia6Tomoyo Taniguchi7Soe Moe Thu Win8Isao Ohashi9Emmanuel Igwaro Odongo-Aginya10Khin Myo Aye11Mon Mon12Kyu Kyu Win13Kei Ota14Yukari Torisu15Siripen Panthuwong16Eisaku Kimura17Nirianne M. Q. Palacpac18Taisei Kikuchi19Tetsuo Hirata20Shidow Torisu21Hajime Hisaeda22Toshihiro Horii23Jiro Fujita24Wah Win Htike25Haruhiko Maruyama26Division of Parasitology, Department of Infectious Diseases, Faculty of Medicine, University of MiyazakiDepartment of Microbiology, University of Medicine 1Department of Internal Medicine, Faculty of Medicine, Prince of Songkla UniversityDepartment of Environmental Parasitology, Tokyo Medical and Dental UniversityDepartment of Endoscopy, University of the Ryukyus HospitalDepartment of Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the RyukyusDepartment of Microbiology and Immunology, Faculty of Medicine, Gulu UniversityDepartment of Parasitology, Graduate School of Medicine, Gunma UniversityDepartment of Microbiology, University of Medicine 1Department of Medical Technology, Koshimizu Red Cross HospitalDepartment of Microbiology and Immunology, Faculty of Medicine, Gulu UniversityDivision of Parasitology, Department of Infectious Diseases, Faculty of Medicine, University of MiyazakiDepartment of Microbiology, University of Medicine 1Department of Microbiology, University of Medicine 1Department of Emergency and General Medicine, Koshimizu Red Cross HospitalSection of Oncopathology and Regenerative Biology, Faculty of Medicine, University of MiyazakiDepartment of Internal Medicine, Faculty of Medicine, Prince of Songkla UniversityDepartment of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka UniversityDivision of Parasitology, Department of Infectious Diseases, Faculty of Medicine, University of MiyazakiDepartment of Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the RyukyusVeterinary Teaching Hospital, Faculty of Agriculture, University of MiyazakiDepartment of Parasitology, Graduate School of Medicine, Gunma UniversityDepartment of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the RyukyusDepartment of Microbiology, University of Medicine 1Division of Parasitology, Department of Infectious Diseases, Faculty of Medicine, University of MiyazakiAbstract Humans and dogs are the two major hosts of Strongyloides stercoralis, an intestinal parasitic nematode. To better understand the phylogenetic relationships among S. stercoralis isolates infecting humans and dogs and to assess the zoonotic potential of this parasite, we analyzed mitochondrial Cox1, nuclear 18S rDNA, 28S rDNA, and a major sperm protein domain-containing protein genes. Overall, our analyses indicated the presence of two distinct lineages of S. stercoralis (referred to as type A and type B). While type A parasites were isolated both from humans and dogs in different countries, type B parasites were found exclusively in dogs, indicating that the type B has not adapted to infect humans. These epidemiological data, together with the close phylogenetic relationship of S. stercoralis with S. procyonis, a Strongyloides parasite of raccoons, possibly indicates that S. stercoralis originally evolved as a canid parasite, and later spread into humans. The inability to infect humans might be an ancestral character of this species and the type B might be surmised to be an origin population from which human-infecting strains are derived.https://doi.org/10.1038/s41598-017-05049-x