Kadar Adiponektin Sebagai Faktor Risiko Penebalan Tunika Intima Media Arteri Karotis

• Main Authors: Hadi Juanda, Toni MA, Undang Ruhimat, Ernijati Suardi
• Format: Article
• Language: English
• Published: Universitas Padjajaran 2009-06-01
• Series: Majalah Kedokteran Bandung
• Subjects: Adiponectin; cardiovascular disease; CIMT
• Online Access: http://journal.fk.unpad.ac.id/index.php/mkb/article/view/186

Cardiovascular diseases remain a major health problem and the leading cause of mortality both in industrialized and developing country, despite the improvement in its prevention and management. Ultrasonography (USG) can be used in the evaluation and early diagnosis of subclinical atherosclerosis to predict cardiovascular events in the future. Carotid intima-medial thickness (CIMT) is a surrogate of vascular dysfunction especially coronary vessels. Adiponectin has anti-inflammatory and anti-atherogenic properties, that is thought to be beneficial because of its cardioprotective effect. However the studies in the role of adiponectin in human is limited and earlier studies found conflicting results. To evaluate the role of adiponectin as a risk factor of carotid artery intima-medial thickening, we conducted this case-control study. The subjects were obese male and female between 40-59 years of age, who were evaluated by carotid artery intima-medial ultrasonography. Exclusion criteria were congestive heart failure, coronary heart disease, stroke and glucocorticoid treatment. Forty subjects with carotid artery intima-medial thickening (cases) and 40 subjects without thickening (control). Adiponectin levels in case group were lower than in control group, 4.1 ìg/mL (SB 1.7) and 6.0 ìg/mL (SB 3.0), respectively. Statistical analysis with chi square test with confidence interval (CI) 95% (1.05-12.78), OR 3.67 with p=0.04 (p<0.05) showed that adiponectin is a significant risk factor of carotid artery intima-medial thickening together with diabetes mellitus, hypertension, and metabolic syndrome. This study found the cut-off point of adiponectin was 5.09 ug/dL with ROC 0.682, CI 95% (0.569-0.782), sensitivity 77.5% and specificity 55,0%. Conclusion: low adiponectin level (<5,09 ug/dL) is a risk factor of developing carotid artery intima-medial thickening.