Penicillin treatment for patients with Community-Acquired Pneumonia in Denmark: a retrospective cohort study
Abstract Background Community-acquired pneumonia (CAP) is a severe infection, with high mortality. Antibiotic strategies for CAP differ across Europe. The objective of the study was to describe the epidemiology of CAP in Denmark and evaluate the prognosis of patients empirically treated with penicil...
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doaj-7715beaeea674e77bff94efe3e941aea2020-11-25T00:43:59ZengBMCBMC Pulmonary Medicine1471-24662017-04-011711910.1186/s12890-017-0404-8Penicillin treatment for patients with Community-Acquired Pneumonia in Denmark: a retrospective cohort studyGertrud Baunbæk Egelund0Andreas Vestergaard Jensen1Stine Bang Andersen2Pelle Trier Petersen3Bjarne Ørskov Lindhardt4Christian von Plessen5Gernot Rohde6Pernille Ravn7Department of Pulmonary and Infectious Diseases, Nordsjaellands HospitalDepartment of Pulmonary and Infectious Diseases, Nordsjaellands HospitalDepartment of Pulmonary and Infectious Diseases, Nordsjaellands HospitalDepartment of Pulmonary and Infectious Diseases, Nordsjaellands HospitalDepartment of Infectious Diseases, Hvidovre HospitalCenter for Quality, Region of Southern DenmarkDepartment of Respiratory Medicine, Maastricht University Medical CenterDepartment of Pulmonary and Infectious Diseases, Nordsjaellands HospitalAbstract Background Community-acquired pneumonia (CAP) is a severe infection, with high mortality. Antibiotic strategies for CAP differ across Europe. The objective of the study was to describe the epidemiology of CAP in Denmark and evaluate the prognosis of patients empirically treated with penicillin-G/V monotherapy. Methods Retrospective cohort study including hospitalized patients with x-ray confirmed CAP. We calculated the population-based incidence, reviewed types of empiric antibiotics and duration of antibiotic treatment. We evaluated the association between mortality and treatment with empiric penicillin-G/V using logistic regression analysis. Results We included 1320 patients. The incidence of hospitalized CAP was 3.1/1000 inhabitants. Median age was 71 years (IQR; 58–81) and in-hospital mortality was 8%. Median duration of antibiotic treatment was 10 days (IQR; 8–12). In total 45% were treated with penicillin-G/V as empiric monotherapy and they did not have a higher mortality compared to patients treated with broader-spectrum antibiotics (OR 0.92, CI 95% 0.55–1.53). Conclusion The duration of treatment exceeded recommendations in European guidelines. Empiric monotherapy with penicillin-G/V was commonly used and not associated with increased mortality in patients with mild to moderate pneumonia. Our results are in agreement with current conservative antibiotic strategy as outlined in the Danish guidelines.http://link.springer.com/article/10.1186/s12890-017-0404-8Community-acquired pneumoniaIncidencePenicillinPrognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gertrud Baunbæk Egelund Andreas Vestergaard Jensen Stine Bang Andersen Pelle Trier Petersen Bjarne Ørskov Lindhardt Christian von Plessen Gernot Rohde Pernille Ravn |
spellingShingle |
Gertrud Baunbæk Egelund Andreas Vestergaard Jensen Stine Bang Andersen Pelle Trier Petersen Bjarne Ørskov Lindhardt Christian von Plessen Gernot Rohde Pernille Ravn Penicillin treatment for patients with Community-Acquired Pneumonia in Denmark: a retrospective cohort study BMC Pulmonary Medicine Community-acquired pneumonia Incidence Penicillin Prognosis |
author_facet |
Gertrud Baunbæk Egelund Andreas Vestergaard Jensen Stine Bang Andersen Pelle Trier Petersen Bjarne Ørskov Lindhardt Christian von Plessen Gernot Rohde Pernille Ravn |
author_sort |
Gertrud Baunbæk Egelund |
title |
Penicillin treatment for patients with Community-Acquired Pneumonia in Denmark: a retrospective cohort study |
title_short |
Penicillin treatment for patients with Community-Acquired Pneumonia in Denmark: a retrospective cohort study |
title_full |
Penicillin treatment for patients with Community-Acquired Pneumonia in Denmark: a retrospective cohort study |
title_fullStr |
Penicillin treatment for patients with Community-Acquired Pneumonia in Denmark: a retrospective cohort study |
title_full_unstemmed |
Penicillin treatment for patients with Community-Acquired Pneumonia in Denmark: a retrospective cohort study |
title_sort |
penicillin treatment for patients with community-acquired pneumonia in denmark: a retrospective cohort study |
publisher |
BMC |
series |
BMC Pulmonary Medicine |
issn |
1471-2466 |
publishDate |
2017-04-01 |
description |
Abstract Background Community-acquired pneumonia (CAP) is a severe infection, with high mortality. Antibiotic strategies for CAP differ across Europe. The objective of the study was to describe the epidemiology of CAP in Denmark and evaluate the prognosis of patients empirically treated with penicillin-G/V monotherapy. Methods Retrospective cohort study including hospitalized patients with x-ray confirmed CAP. We calculated the population-based incidence, reviewed types of empiric antibiotics and duration of antibiotic treatment. We evaluated the association between mortality and treatment with empiric penicillin-G/V using logistic regression analysis. Results We included 1320 patients. The incidence of hospitalized CAP was 3.1/1000 inhabitants. Median age was 71 years (IQR; 58–81) and in-hospital mortality was 8%. Median duration of antibiotic treatment was 10 days (IQR; 8–12). In total 45% were treated with penicillin-G/V as empiric monotherapy and they did not have a higher mortality compared to patients treated with broader-spectrum antibiotics (OR 0.92, CI 95% 0.55–1.53). Conclusion The duration of treatment exceeded recommendations in European guidelines. Empiric monotherapy with penicillin-G/V was commonly used and not associated with increased mortality in patients with mild to moderate pneumonia. Our results are in agreement with current conservative antibiotic strategy as outlined in the Danish guidelines. |
topic |
Community-acquired pneumonia Incidence Penicillin Prognosis |
url |
http://link.springer.com/article/10.1186/s12890-017-0404-8 |
work_keys_str_mv |
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