First case report of cutaneous sporotrichosis ( species) in a cat in the UK
Case summary A 12-year-old female neutered indoor–outdoor domestic longhair cat presented with frequent sneezing and a nodular, suppurative lesion on its dorsal nose. Histopathological examination revealed a fungal granuloma. PCR and sequencing of the ribosomal internal transcribed spacers (ITS) reg...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2020-02-01
|
Series: | Journal of Feline Medicine and Surgery Open Reports |
Online Access: | https://doi.org/10.1177/2055116920906001 |
id |
doaj-7717cbbf9c4f4c638c398379de525c76 |
---|---|
record_format |
Article |
spelling |
doaj-7717cbbf9c4f4c638c398379de525c762020-11-25T03:03:33ZengSAGE PublishingJournal of Feline Medicine and Surgery Open Reports2055-11692020-02-01610.1177/2055116920906001First case report of cutaneous sporotrichosis ( species) in a cat in the UKNikoleta Makri0Gavin K Paterson1Fiona Gregge2Catriona Urquhart3Tim Nuttall4Dermatology Service, Hospital for Small Animals, University of Edinburgh, Royal (Dick) School of Veterinary Studies, Roslin, UKEaster Bush Pathology, University of Edinburgh, Royal (Dick) School of Veterinary Studies, Roslin, UKAberdeen PDSA Pet Hospital, Aberdeen, UKAbervet (Nigg Kirk Hall Surgery), Aberdeen, UKDermatology Service, Hospital for Small Animals, University of Edinburgh, Royal (Dick) School of Veterinary Studies, Roslin, UKCase summary A 12-year-old female neutered indoor–outdoor domestic longhair cat presented with frequent sneezing and a nodular, suppurative lesion on its dorsal nose. Histopathological examination revealed a fungal granuloma. PCR and sequencing of the ribosomal internal transcribed spacers (ITS) regions (ITS-F and ITS-R) confirmed an infection with a Sporothrix species. Further sequencing of the beta-tubulin and calmodulin genes confirmed Sporothrix humicola , which lies within the Sporothrix pallida complex. The cat had concurrent diabetes mellitus, which responded to insulin therapy and diet. Oral itraconazole at 10 mg/kg PO q24h resulted in resolution of the lesions after 12 months. Treatment was well tolerated. Relevance and novel information This is the first report of sporotrichosis in a cat in the UK and only the fifth worldwide involving the S pallida complex. Clinicians, pathologists and microbiologists need to be aware of the potential of Sporothrix infections in the UK and the ability of S pallida complex to cause opportunistic infections. Molecular techniques can achieve rapid and accurate identification of rare fungal organisms. A precise diagnosis with molecular testing can provide information regarding prognosis, treatment and zoonotic implications.https://doi.org/10.1177/2055116920906001 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nikoleta Makri Gavin K Paterson Fiona Gregge Catriona Urquhart Tim Nuttall |
spellingShingle |
Nikoleta Makri Gavin K Paterson Fiona Gregge Catriona Urquhart Tim Nuttall First case report of cutaneous sporotrichosis ( species) in a cat in the UK Journal of Feline Medicine and Surgery Open Reports |
author_facet |
Nikoleta Makri Gavin K Paterson Fiona Gregge Catriona Urquhart Tim Nuttall |
author_sort |
Nikoleta Makri |
title |
First case report of cutaneous sporotrichosis ( species) in a cat in the UK |
title_short |
First case report of cutaneous sporotrichosis ( species) in a cat in the UK |
title_full |
First case report of cutaneous sporotrichosis ( species) in a cat in the UK |
title_fullStr |
First case report of cutaneous sporotrichosis ( species) in a cat in the UK |
title_full_unstemmed |
First case report of cutaneous sporotrichosis ( species) in a cat in the UK |
title_sort |
first case report of cutaneous sporotrichosis ( species) in a cat in the uk |
publisher |
SAGE Publishing |
series |
Journal of Feline Medicine and Surgery Open Reports |
issn |
2055-1169 |
publishDate |
2020-02-01 |
description |
Case summary A 12-year-old female neutered indoor–outdoor domestic longhair cat presented with frequent sneezing and a nodular, suppurative lesion on its dorsal nose. Histopathological examination revealed a fungal granuloma. PCR and sequencing of the ribosomal internal transcribed spacers (ITS) regions (ITS-F and ITS-R) confirmed an infection with a Sporothrix species. Further sequencing of the beta-tubulin and calmodulin genes confirmed Sporothrix humicola , which lies within the Sporothrix pallida complex. The cat had concurrent diabetes mellitus, which responded to insulin therapy and diet. Oral itraconazole at 10 mg/kg PO q24h resulted in resolution of the lesions after 12 months. Treatment was well tolerated. Relevance and novel information This is the first report of sporotrichosis in a cat in the UK and only the fifth worldwide involving the S pallida complex. Clinicians, pathologists and microbiologists need to be aware of the potential of Sporothrix infections in the UK and the ability of S pallida complex to cause opportunistic infections. Molecular techniques can achieve rapid and accurate identification of rare fungal organisms. A precise diagnosis with molecular testing can provide information regarding prognosis, treatment and zoonotic implications. |
url |
https://doi.org/10.1177/2055116920906001 |
work_keys_str_mv |
AT nikoletamakri firstcasereportofcutaneoussporotrichosisspeciesinacatintheuk AT gavinkpaterson firstcasereportofcutaneoussporotrichosisspeciesinacatintheuk AT fionagregge firstcasereportofcutaneoussporotrichosisspeciesinacatintheuk AT catrionaurquhart firstcasereportofcutaneoussporotrichosisspeciesinacatintheuk AT timnuttall firstcasereportofcutaneoussporotrichosisspeciesinacatintheuk |
_version_ |
1724685177911771136 |