Radioprotective Effects of Zinc and Selenium on Mice Spermatogenesis
Background: Spermatogenesis system is one of the most radiosensitive organs in the body. A usual therapeutic dose of radiation such as the conventional 2 Gy in each fraction of radiotherapy and lower doses seen in diagnostic radiology or a radiation disaster affect the process of spermatogenesis pot...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Shiraz University of Medical Sciences
2020-12-01
|
Series: | Journal of Biomedical Physics and Engineering |
Subjects: | |
Online Access: | https://jbpe.sums.ac.ir/article_45715_f886c260449abe35652c7dfe9d05f2ee.pdf |
id |
doaj-77197018d3464d20b78015571876baa8 |
---|---|
record_format |
Article |
spelling |
doaj-77197018d3464d20b78015571876baa82020-12-19T09:51:24ZengShiraz University of Medical SciencesJournal of Biomedical Physics and Engineering2251-72002251-72002020-12-0110670771210.31661/jbpe.v0i0.95745715Radioprotective Effects of Zinc and Selenium on Mice SpermatogenesisH Bagheri0A Salajegheh1A Javadi2P Amini3B Shekarchi4D Shabeeb5A Eleojo Musa6M Najafi7MSc, Radiation and Wave Research Center, Aja University of Medical Sciences, Tehran, IranMSc, Radiation and Wave Research Center, Aja University of Medical Sciences, Tehran, IranMD, Department of Pathology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranMSc, Department of Radiology, Faculty of Paramedical, Tehran University of Medical Sciences, Tehran, IranMD, Radiation and Wave Research Center, Aja University of Medical Sciences, Tehran, IranPhD, Department of Physiology, College of Medicine, University of Misan, Misan, IraqMSc, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences (International Campus), Tehran, IranPhD, Medical Technology Research Center, Kermanshah University of Medical Sciences, Kermanshah, IranBackground: Spermatogenesis system is one of the most radiosensitive organs in the body. A usual therapeutic dose of radiation such as the conventional 2 Gy in each fraction of radiotherapy and lower doses seen in diagnostic radiology or a radiation disaster affect the process of spermatogenesis potently. Selenium and zinc are two important elements playing key roles in the development of sperms and also have radioprotective effects. Objective: In this study aims to evaluate the radioprotective effect of zinc and selenium against radiation-induced mice testis injury.Material and Methods: In this experimental study, 30 mice were divided equally into 6 groups, including control selenium treated, zinc treated, radiation, radiation + selenium, radiation + zinc. Treatments started from 2 days before irradiation with 2 Gy cobalt-60 gamma rays. After 37 days, all mice were killed for histopathological evaluations. Results: Results showed that exposure to radiation caused a potent effect on spermatogenesis system. Treatment with selenium reversed these radiation effects potently, while zinc had some limited protective effects. Zinc treatment itself caused a detrimental effect on epididymis and, in combination with radiation, it leads to more damage to seminiferous tubules. Conclusion: In contrast to previous studies that proposed zinc to protect spermatogenesis against various toxic agents, results of this study showed that although zinc may protect from some parameters, it potentiates radiation damage on seminiferous tubules and has a detrimental effect on the epididymis. By contrast, zinc and selenium could alleviate radiation-induced toxicity on the most of the evaluated parameters.https://jbpe.sums.ac.ir/article_45715_f886c260449abe35652c7dfe9d05f2ee.pdfradiationspermatogenesiszincseleniumseminiferous tubulesepididymis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
H Bagheri A Salajegheh A Javadi P Amini B Shekarchi D Shabeeb A Eleojo Musa M Najafi |
spellingShingle |
H Bagheri A Salajegheh A Javadi P Amini B Shekarchi D Shabeeb A Eleojo Musa M Najafi Radioprotective Effects of Zinc and Selenium on Mice Spermatogenesis Journal of Biomedical Physics and Engineering radiation spermatogenesis zinc selenium seminiferous tubules epididymis |
author_facet |
H Bagheri A Salajegheh A Javadi P Amini B Shekarchi D Shabeeb A Eleojo Musa M Najafi |
author_sort |
H Bagheri |
title |
Radioprotective Effects of Zinc and Selenium on Mice Spermatogenesis |
title_short |
Radioprotective Effects of Zinc and Selenium on Mice Spermatogenesis |
title_full |
Radioprotective Effects of Zinc and Selenium on Mice Spermatogenesis |
title_fullStr |
Radioprotective Effects of Zinc and Selenium on Mice Spermatogenesis |
title_full_unstemmed |
Radioprotective Effects of Zinc and Selenium on Mice Spermatogenesis |
title_sort |
radioprotective effects of zinc and selenium on mice spermatogenesis |
publisher |
Shiraz University of Medical Sciences |
series |
Journal of Biomedical Physics and Engineering |
issn |
2251-7200 2251-7200 |
publishDate |
2020-12-01 |
description |
Background: Spermatogenesis system is one of the most radiosensitive organs in the body. A usual therapeutic dose of radiation such as the conventional 2 Gy in each fraction of radiotherapy and lower doses seen in diagnostic radiology or a radiation disaster affect the process of spermatogenesis potently. Selenium and zinc are two important elements playing key roles in the development of sperms and also have radioprotective effects. Objective: In this study aims to evaluate the radioprotective effect of zinc and selenium against radiation-induced mice testis injury.Material and Methods: In this experimental study, 30 mice were divided equally into 6 groups, including control selenium treated, zinc treated, radiation, radiation + selenium, radiation + zinc. Treatments started from 2 days before irradiation with 2 Gy cobalt-60 gamma rays. After 37 days, all mice were killed for histopathological evaluations. Results: Results showed that exposure to radiation caused a potent effect on spermatogenesis system. Treatment with selenium reversed these radiation effects potently, while zinc had some limited protective effects. Zinc treatment itself caused a detrimental effect on epididymis and, in combination with radiation, it leads to more damage to seminiferous tubules. Conclusion: In contrast to previous studies that proposed zinc to protect spermatogenesis against various toxic agents, results of this study showed that although zinc may protect from some parameters, it potentiates radiation damage on seminiferous tubules and has a detrimental effect on the epididymis. By contrast, zinc and selenium could alleviate radiation-induced toxicity on the most of the evaluated parameters. |
topic |
radiation spermatogenesis zinc selenium seminiferous tubules epididymis |
url |
https://jbpe.sums.ac.ir/article_45715_f886c260449abe35652c7dfe9d05f2ee.pdf |
work_keys_str_mv |
AT hbagheri radioprotectiveeffectsofzincandseleniumonmicespermatogenesis AT asalajegheh radioprotectiveeffectsofzincandseleniumonmicespermatogenesis AT ajavadi radioprotectiveeffectsofzincandseleniumonmicespermatogenesis AT pamini radioprotectiveeffectsofzincandseleniumonmicespermatogenesis AT bshekarchi radioprotectiveeffectsofzincandseleniumonmicespermatogenesis AT dshabeeb radioprotectiveeffectsofzincandseleniumonmicespermatogenesis AT aeleojomusa radioprotectiveeffectsofzincandseleniumonmicespermatogenesis AT mnajafi radioprotectiveeffectsofzincandseleniumonmicespermatogenesis |
_version_ |
1724377423276933120 |