Conduction block as an electrophysiological phenomenon: a review of the literature
Evaluation and interpretation of electrophysiological phenomena often plays an important role in the diagnosis of neuromuscular diseases. Motor nerve conduction block is a reduction of either amplitude or area of the compound motor action potential elicited by proximal to distal motor nerve stimulat...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | Russian |
Published: |
ABV-press
2019-04-01
|
Series: | Nervno-Myšečnye Bolezni |
Subjects: | |
Online Access: | https://nmb.abvpress.ru/jour/article/view/310 |
id |
doaj-771aff1d1e5946e6bcd473edd32c5074 |
---|---|
record_format |
Article |
spelling |
doaj-771aff1d1e5946e6bcd473edd32c50742021-07-29T08:13:29ZrusABV-pressNervno-Myšečnye Bolezni2222-87212413-04432019-04-0191122310.17650/2222-8721-2019-9-1-12-23228Conduction block as an electrophysiological phenomenon: a review of the literatureS. S. Nikitin0A. F. Murtazina1D. S. Druzhinin2Association of Neuromuscular Disorders Specialists, Medical Center “Practical Neurology”Association of Neuromuscular Disorders Specialists, Medical Center “Practical Neurology”; Federal State Budgetary Scientific Institution “Research Centre for Medical Genetics”Yaroslavl’ State Medical University, Ministry of Health of RussiaEvaluation and interpretation of electrophysiological phenomena often plays an important role in the diagnosis of neuromuscular diseases. Motor nerve conduction block is a reduction of either amplitude or area of the compound motor action potential elicited by proximal to distal motor nerve stimulation. Today, the value of conduction block in the diagnosis of demyelinating and axonal neuropathies, as well as the diagnostic criteria for these disorders, are still under discussion.Objective of the review of the literature is to highlight the value of conduction block as an electrophysiological phenomenon in the light of clinical manifestations. There is no consensus in the literature which motor response parameters should be used as partial conduction block criteria. The diversity of pathogenic forms in which conduction block can be registered does not allow to consider the phenomenon as a sign of only demyelinating lesions, and the term conduction block should be considered as a pure electrophysiological phenomenon. Different pathophysiological mechanisms of conduction block formation should be studied separately within each nosology. Conduction block detection does not allow to specify a particular diagnosis, however, in conjunction with clinical and anamnestic data, it may be the main argument in the diagnosis of a number of peripheral nerves diseases.https://nmb.abvpress.ru/jour/article/view/310conduction blocknerve conduction studytemporal dispersiondemyelinating neuropathyaxonal neuropathycompression neuropathyguillain–barre syndromechronic inflammatory demyelinating polyneuropathymultifocal motor neuropathy |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
S. S. Nikitin A. F. Murtazina D. S. Druzhinin |
spellingShingle |
S. S. Nikitin A. F. Murtazina D. S. Druzhinin Conduction block as an electrophysiological phenomenon: a review of the literature Nervno-Myšečnye Bolezni conduction block nerve conduction study temporal dispersion demyelinating neuropathy axonal neuropathy compression neuropathy guillain–barre syndrome chronic inflammatory demyelinating polyneuropathy multifocal motor neuropathy |
author_facet |
S. S. Nikitin A. F. Murtazina D. S. Druzhinin |
author_sort |
S. S. Nikitin |
title |
Conduction block as an electrophysiological phenomenon: a review of the literature |
title_short |
Conduction block as an electrophysiological phenomenon: a review of the literature |
title_full |
Conduction block as an electrophysiological phenomenon: a review of the literature |
title_fullStr |
Conduction block as an electrophysiological phenomenon: a review of the literature |
title_full_unstemmed |
Conduction block as an electrophysiological phenomenon: a review of the literature |
title_sort |
conduction block as an electrophysiological phenomenon: a review of the literature |
publisher |
ABV-press |
series |
Nervno-Myšečnye Bolezni |
issn |
2222-8721 2413-0443 |
publishDate |
2019-04-01 |
description |
Evaluation and interpretation of electrophysiological phenomena often plays an important role in the diagnosis of neuromuscular diseases. Motor nerve conduction block is a reduction of either amplitude or area of the compound motor action potential elicited by proximal to distal motor nerve stimulation. Today, the value of conduction block in the diagnosis of demyelinating and axonal neuropathies, as well as the diagnostic criteria for these disorders, are still under discussion.Objective of the review of the literature is to highlight the value of conduction block as an electrophysiological phenomenon in the light of clinical manifestations. There is no consensus in the literature which motor response parameters should be used as partial conduction block criteria. The diversity of pathogenic forms in which conduction block can be registered does not allow to consider the phenomenon as a sign of only demyelinating lesions, and the term conduction block should be considered as a pure electrophysiological phenomenon. Different pathophysiological mechanisms of conduction block formation should be studied separately within each nosology. Conduction block detection does not allow to specify a particular diagnosis, however, in conjunction with clinical and anamnestic data, it may be the main argument in the diagnosis of a number of peripheral nerves diseases. |
topic |
conduction block nerve conduction study temporal dispersion demyelinating neuropathy axonal neuropathy compression neuropathy guillain–barre syndrome chronic inflammatory demyelinating polyneuropathy multifocal motor neuropathy |
url |
https://nmb.abvpress.ru/jour/article/view/310 |
work_keys_str_mv |
AT ssnikitin conductionblockasanelectrophysiologicalphenomenonareviewoftheliterature AT afmurtazina conductionblockasanelectrophysiologicalphenomenonareviewoftheliterature AT dsdruzhinin conductionblockasanelectrophysiologicalphenomenonareviewoftheliterature |
_version_ |
1721256914770198528 |