The tacrolimus metabolism rate influences renal function after kidney transplantation.
The effective calcineurin inhibitor (CNI) tacrolimus (Tac) is an integral part of the standard immunosuppressive regimen after renal transplantation (RTx). However, as a potent CNI it has nephrotoxic potential leading to impaired renal function in some cases. Therefore, it is of high clinical impact...
Main Authors: | Gerold Thölking, Christian Fortmann, Raphael Koch, Hans Ulrich Gerth, Dirk Pabst, Hermann Pavenstädt, Iyad Kabar, Anna Hüsing, Heiner Wolters, Stefan Reuter, Barbara Suwelack |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4207775?pdf=render |
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