Aberrant expression of functional BAFF-system receptors by malignant B-cell precursors impacts leukemia cell survival.

Aberrant expression of functional BAFF-system receptors by malignant B-cell precursors impacts leukemia cell survival.

Despite exhibiting oncogenic events, patient's leukemia cells are responsive and dependent on signals from their malignant bone marrow (BM) microenvironment, which modulate their survival, cell cycle progression, trafficking and resistance to chemotherapy. Identification of the signaling pathwa...

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Bibliographic Details
Main Authors: Sara Maia, Marc Pelletier, Jixin Ding, Yen-Ming Hsu, Stephen E Sallan, Sambasiva P Rao, Lee M Nadler, Angelo A Cardoso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3110793?pdf=render

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