Severe Fatigue is an Important Factor in the Prognosis of Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib

• Main Authors: Qiu X, Li M, Wu L, Xin Y, Mu S, Li T, Song K
• Format: Article
• Language: English
• Published: Dove Medical Press 2020-09-01
• Series: Cancer Management and Research
• Subjects: hepatocellular carcinoma; sorafenib; fatigue; survival
• Online Access: https://www.dovepress.com/severe-fatigue-is-an-important-factor-in-the-prognosis-of-patients-wit-peer-reviewed-article-CMAR

Xuan Qiu, Manjiang Li, Liqun Wu, Yang Xin, Siyu Mu, Tianxiang Li, Kangjian Song Liver Disease Center, The Affiliated Hospital of Qingdao University, Qingdao 266003, People’s Republic of ChinaCorrespondence: Liqun WuLiver Disease Center, The Affiliated Hospital of Qingdao University, No. 59 Haier Road, Laoshan District, Qingdao, Shandong 266003, People’s Republic of ChinaTel [phone]Email [e-mail]: To investigate the effects of fatigue on the survival of patients with advanced hepatocellular carcinoma treated with sorafenib.Patients and Methods: A retrospective analysis of 182 cases of patients with advanced hepatocellular carcinoma treated with sorafenib in our hospital from October 1, 2008, to October 31, 2017, showed clinical and pathological data and follow-up results. The clinical and pathological data as well as follow-up results of 182 patients with advanced hepatocellular carcinoma treated with sorafenib in our hospital from October 1, 2008, to October 31, 2018, were retrospectively analyzed. All patients were treated for at least 3 months. Patients were divided into three groups: fatigue grade I (n=74), fatigue grade II (n=62), and fatigue grade III (n=46), according to National Cancer Institute common terminology criteria for adverse events (NCI CTCAE) version 5.0. Survival analysis between groups was performed by the Kaplan–Meier method (Log rank test), continuous variables were analyzed by t-test, and categorical variables were analyzed by chi-square test.Results: The overall survival (OS) of patients who were relieved of fatigue was 33.0± 9.3 months, whereas the OS of patients who were not relieved of fatigue was 15.0± 1.8 months (P< 0.000). Furthermore, the time to progress (TTP) of patients who were relieved of fatigue by resting was 20.3 ± 10.9 months compared to a TTP of 7.7 ± 1.0 months in patients who were not relieved of fatigue (P< 0.000).Conclusion: Patients, especially the elderly and infirm, were more susceptible to toxicity.Keywords: hepatocellular carcinoma, sorafenib, fatigue, survival