Maternal Obesity, Inflammation, and Developmental Programming
The prevalence of obesity, especially in women of child-bearing age, is a global health concern. In addition to increasing the immediate risk of gestational complications, there is accumulating evidence that maternal obesity also has long-term consequences for the offspring. The concept of developme...
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doaj-7726cd302bdf4b319875086ba70ae0182020-11-24T21:41:07ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/418975418975Maternal Obesity, Inflammation, and Developmental ProgrammingStephanie A. Segovia0Mark H. Vickers1Clint Gray2Clare M. Reynolds3Liggins Institute and Gravida, National Centre for Growth and Development, University of Auckland, Auckland 1142, New ZealandLiggins Institute and Gravida, National Centre for Growth and Development, University of Auckland, Auckland 1142, New ZealandLiggins Institute and Gravida, National Centre for Growth and Development, University of Auckland, Auckland 1142, New ZealandLiggins Institute and Gravida, National Centre for Growth and Development, University of Auckland, Auckland 1142, New ZealandThe prevalence of obesity, especially in women of child-bearing age, is a global health concern. In addition to increasing the immediate risk of gestational complications, there is accumulating evidence that maternal obesity also has long-term consequences for the offspring. The concept of developmental programming describes the process in which an environmental stimulus, including altered nutrition, during critical periods of development can program alterations in organogenesis, tissue development, and metabolism, predisposing offspring to obesity and metabolic and cardiovascular disorders in later life. Although the mechanisms underpinning programming of metabolic disorders remain poorly defined, it has become increasingly clear that low-grade inflammation is associated with obesity and its comorbidities. This review will discuss maternal metainflammation as a mediator of programming in insulin sensitive tissues in offspring. Use of nutritional anti-inflammatories in pregnancy including omega 3 fatty acids, resveratrol, curcumin, and taurine may provide beneficial intervention strategies to ameliorate maternal obesity-induced programming.http://dx.doi.org/10.1155/2014/418975 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stephanie A. Segovia Mark H. Vickers Clint Gray Clare M. Reynolds |
spellingShingle |
Stephanie A. Segovia Mark H. Vickers Clint Gray Clare M. Reynolds Maternal Obesity, Inflammation, and Developmental Programming BioMed Research International |
author_facet |
Stephanie A. Segovia Mark H. Vickers Clint Gray Clare M. Reynolds |
author_sort |
Stephanie A. Segovia |
title |
Maternal Obesity, Inflammation, and Developmental Programming |
title_short |
Maternal Obesity, Inflammation, and Developmental Programming |
title_full |
Maternal Obesity, Inflammation, and Developmental Programming |
title_fullStr |
Maternal Obesity, Inflammation, and Developmental Programming |
title_full_unstemmed |
Maternal Obesity, Inflammation, and Developmental Programming |
title_sort |
maternal obesity, inflammation, and developmental programming |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
The prevalence of obesity, especially in women of child-bearing age, is a global health concern. In addition to increasing the immediate risk of gestational complications, there is accumulating evidence that maternal obesity also has long-term consequences for the offspring. The concept of developmental programming describes the process in which an environmental stimulus, including altered nutrition, during critical periods of development can program alterations in organogenesis, tissue development, and metabolism, predisposing offspring to obesity and metabolic and cardiovascular disorders in later life. Although the mechanisms underpinning programming of metabolic disorders remain poorly defined, it has become increasingly clear that low-grade inflammation is associated with obesity and its comorbidities. This review will discuss maternal metainflammation as a mediator of programming in insulin sensitive tissues in offspring. Use of nutritional anti-inflammatories in pregnancy including omega 3 fatty acids, resveratrol, curcumin, and taurine may provide beneficial intervention strategies to ameliorate maternal obesity-induced programming. |
url |
http://dx.doi.org/10.1155/2014/418975 |
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AT stephanieasegovia maternalobesityinflammationanddevelopmentalprogramming AT markhvickers maternalobesityinflammationanddevelopmentalprogramming AT clintgray maternalobesityinflammationanddevelopmentalprogramming AT claremreynolds maternalobesityinflammationanddevelopmentalprogramming |
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