Biological activity of poly(ADP-ribose)polymerase-1
Poly(ADP-ribose)polymerase-1 (PARP-1) catalyzes the polymerization of ADP-ribose units from NAD[sup] [/sup] modules on target proteins, resulting in the attachment of linear or branched polymers. PARP-1 and its product poly(ADP-ribose) – PAR have recently received considerable attention because of t...
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Index Copernicus International S.A.
2010-07-01
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doaj-7726fb7257854a18a9da16d6550259002020-11-25T00:16:13ZengIndex Copernicus International S.A.Postępy Higieny i Medycyny Doświadczalnej0032-54491732-26932010-07-0164840537344363Biological activity of poly(ADP-ribose)polymerase-1Zofia M. KiliańskaJolanta ŻołnierczykJózefa Węsierska-GądekPoly(ADP-ribose)polymerase-1 (PARP-1) catalyzes the polymerization of ADP-ribose units from NAD[sup] [/sup] modules on target proteins, resulting in the attachment of linear or branched polymers. PARP-1 and its product poly(ADP-ribose) – PAR have recently received considerable attention because of their involvement in a wide range of cellular processes including chromatin modification, metabolism of nucleic acids, transcription regulation, and cell death. This review summarizes recent work on modular structure of six functional domains (A–F) of PARP-1 molecule in the context of three classic domains, i.e., DNA binding (DBD), automodification (AD) and catalytic (CD) released by proteolytic enzymes. A special attention is paid to subcellular localization and molecular mechanisms of PARP-1 posttranslational modifications, such as: poly(ADP-ribosylation), phosphorylation, acetylation and sumolyation. In addition, main functions of PARP-1 are discussed, focusing on the activity of this enzyme in DNA damage detection and repair, genome stability, and cell death.http://journals.indexcopernicus.com/fulltxt.php?ICID=915606PARP-1budowa domenowamodyfikacje potranslacyjnenaprawa DNAśmierć komórkowa |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zofia M. Kiliańska Jolanta Żołnierczyk Józefa Węsierska-Gądek |
spellingShingle |
Zofia M. Kiliańska Jolanta Żołnierczyk Józefa Węsierska-Gądek Biological activity of poly(ADP-ribose)polymerase-1 Postępy Higieny i Medycyny Doświadczalnej PARP-1 budowa domenowa modyfikacje potranslacyjne naprawa DNA śmierć komórkowa |
author_facet |
Zofia M. Kiliańska Jolanta Żołnierczyk Józefa Węsierska-Gądek |
author_sort |
Zofia M. Kiliańska |
title |
Biological activity of poly(ADP-ribose)polymerase-1 |
title_short |
Biological activity of poly(ADP-ribose)polymerase-1 |
title_full |
Biological activity of poly(ADP-ribose)polymerase-1 |
title_fullStr |
Biological activity of poly(ADP-ribose)polymerase-1 |
title_full_unstemmed |
Biological activity of poly(ADP-ribose)polymerase-1 |
title_sort |
biological activity of poly(adp-ribose)polymerase-1 |
publisher |
Index Copernicus International S.A. |
series |
Postępy Higieny i Medycyny Doświadczalnej |
issn |
0032-5449 1732-2693 |
publishDate |
2010-07-01 |
description |
Poly(ADP-ribose)polymerase-1 (PARP-1) catalyzes the polymerization of ADP-ribose units from NAD[sup] [/sup] modules on target proteins, resulting in the attachment of linear or branched polymers. PARP-1 and its product poly(ADP-ribose) – PAR have recently received considerable attention because of their involvement in a wide range of cellular processes including chromatin modification, metabolism of nucleic acids, transcription regulation, and cell death. This review summarizes recent work on modular structure of six functional domains (A–F) of PARP-1 molecule in the context of three classic domains, i.e., DNA binding (DBD), automodification (AD) and catalytic (CD) released by proteolytic enzymes. A special attention is paid to subcellular localization and molecular mechanisms of PARP-1 posttranslational modifications, such as: poly(ADP-ribosylation), phosphorylation, acetylation and sumolyation. In addition, main functions of PARP-1 are discussed, focusing on the activity of this enzyme in DNA damage detection and repair, genome stability, and cell death. |
topic |
PARP-1 budowa domenowa modyfikacje potranslacyjne naprawa DNA śmierć komórkowa |
url |
http://journals.indexcopernicus.com/fulltxt.php?ICID=915606 |
work_keys_str_mv |
AT zofiamkilianska biologicalactivityofpolyadpribosepolymerase1 AT jolantazołnierczyk biologicalactivityofpolyadpribosepolymerase1 AT jozefawesierskagadek biologicalactivityofpolyadpribosepolymerase1 |
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1725383992092393472 |