Antinociceptive effects of the essential oil of Croton nepetaefolius on mice
Croton nepetaefolius Baill., is an aromatic plant native to the northeast of Brazil where it is extensively used in folk medicine as a sedative, orexigen and antispasmodic agent. In the present study the antinociceptive effects of the essential oil of C. nepetaefolius (EOCn), administered orally, we...
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Associação Brasileira de Divulgação Científica
2002-10-01
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000015 |
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doaj-77272f018312440e9d84c2ec066a14d52020-11-24T22:40:38ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2002-10-0135101215121910.1590/S0100-879X2002001000015Antinociceptive effects of the essential oil of Croton nepetaefolius on miceA.P.V. AbdonJ.H. Leal-CardosoA.N. Coelho-de-SouzaS.M. MoraisC.F. SantosCroton nepetaefolius Baill., is an aromatic plant native to the northeast of Brazil where it is extensively used in folk medicine as a sedative, orexigen and antispasmodic agent. In the present study the antinociceptive effects of the essential oil of C. nepetaefolius (EOCn), administered orally, were evaluated in male Swiss mice (20-25 g). In the acetic acid-induced writhing test, EOCn (100 and 300 mg/kg; N = 14 and N = 12, respectively) was effective at the highest dose. In the hot-plate test, EOCn at 30 and 300 mg/kg, but not at 3 mg/kg, significantly increased the latency at all observation times up to the 180th min (N = 12 for each dose). In the formalin test, EOCn significantly reduced paw licking in the second phase of the test at 100 mg/kg (N = 12), but decreased it in both phases at 300 mg/kg (N = 12). At 30 mg/kg, the effect of EOCn did not differ from control values in either phase of the formalin test (N = 6). Pretreatment with naloxone (5 mg/kg, ip) significantly reversed the analgesic effect of morphine (5 mg/kg, sc) on both phases, but not that of EOCn at 300 mg/kg (N = 6) on both phases of the formalin test. The data show that orally administered EOCn promotes a dose-dependent antinociceptive effect whose mechanisms remain to be elucidated.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000015Croton nepetaefoliusEssential oilAnalgesicAntinociceptionFormalin testHot-plate test |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A.P.V. Abdon J.H. Leal-Cardoso A.N. Coelho-de-Souza S.M. Morais C.F. Santos |
spellingShingle |
A.P.V. Abdon J.H. Leal-Cardoso A.N. Coelho-de-Souza S.M. Morais C.F. Santos Antinociceptive effects of the essential oil of Croton nepetaefolius on mice Brazilian Journal of Medical and Biological Research Croton nepetaefolius Essential oil Analgesic Antinociception Formalin test Hot-plate test |
author_facet |
A.P.V. Abdon J.H. Leal-Cardoso A.N. Coelho-de-Souza S.M. Morais C.F. Santos |
author_sort |
A.P.V. Abdon |
title |
Antinociceptive effects of the essential oil of Croton nepetaefolius on mice |
title_short |
Antinociceptive effects of the essential oil of Croton nepetaefolius on mice |
title_full |
Antinociceptive effects of the essential oil of Croton nepetaefolius on mice |
title_fullStr |
Antinociceptive effects of the essential oil of Croton nepetaefolius on mice |
title_full_unstemmed |
Antinociceptive effects of the essential oil of Croton nepetaefolius on mice |
title_sort |
antinociceptive effects of the essential oil of croton nepetaefolius on mice |
publisher |
Associação Brasileira de Divulgação Científica |
series |
Brazilian Journal of Medical and Biological Research |
issn |
0100-879X 1414-431X |
publishDate |
2002-10-01 |
description |
Croton nepetaefolius Baill., is an aromatic plant native to the northeast of Brazil where it is extensively used in folk medicine as a sedative, orexigen and antispasmodic agent. In the present study the antinociceptive effects of the essential oil of C. nepetaefolius (EOCn), administered orally, were evaluated in male Swiss mice (20-25 g). In the acetic acid-induced writhing test, EOCn (100 and 300 mg/kg; N = 14 and N = 12, respectively) was effective at the highest dose. In the hot-plate test, EOCn at 30 and 300 mg/kg, but not at 3 mg/kg, significantly increased the latency at all observation times up to the 180th min (N = 12 for each dose). In the formalin test, EOCn significantly reduced paw licking in the second phase of the test at 100 mg/kg (N = 12), but decreased it in both phases at 300 mg/kg (N = 12). At 30 mg/kg, the effect of EOCn did not differ from control values in either phase of the formalin test (N = 6). Pretreatment with naloxone (5 mg/kg, ip) significantly reversed the analgesic effect of morphine (5 mg/kg, sc) on both phases, but not that of EOCn at 300 mg/kg (N = 6) on both phases of the formalin test. The data show that orally administered EOCn promotes a dose-dependent antinociceptive effect whose mechanisms remain to be elucidated. |
topic |
Croton nepetaefolius Essential oil Analgesic Antinociception Formalin test Hot-plate test |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000015 |
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