Deep Hypothermic Circulatory Arrest Does Not Show Better Protection for Vital Organs Compared with Moderate Hypothermic Circulatory Arrest in Pig Model
Background. Continued debates exist regarding the optimal temperature during hypothermic circulatory arrest in aortic arch repair for patients with type A aortic dissection. This study seeks to examine whether the use of moderate hypothermic circulatory arrest in a pig model provides comparable vita...
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Format: | Article |
Language: | English |
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Hindawi Limited
2019-01-01
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Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2019/1420216 |
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doaj-7728006c872d4446b26dc3df5940155e |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yang Liu Zining Wu Lu Dai Haiyang Li Ming Gong Feng Lan Xinliang Guan Hongjia Zhang |
spellingShingle |
Yang Liu Zining Wu Lu Dai Haiyang Li Ming Gong Feng Lan Xinliang Guan Hongjia Zhang Deep Hypothermic Circulatory Arrest Does Not Show Better Protection for Vital Organs Compared with Moderate Hypothermic Circulatory Arrest in Pig Model BioMed Research International |
author_facet |
Yang Liu Zining Wu Lu Dai Haiyang Li Ming Gong Feng Lan Xinliang Guan Hongjia Zhang |
author_sort |
Yang Liu |
title |
Deep Hypothermic Circulatory Arrest Does Not Show Better Protection for Vital Organs Compared with Moderate Hypothermic Circulatory Arrest in Pig Model |
title_short |
Deep Hypothermic Circulatory Arrest Does Not Show Better Protection for Vital Organs Compared with Moderate Hypothermic Circulatory Arrest in Pig Model |
title_full |
Deep Hypothermic Circulatory Arrest Does Not Show Better Protection for Vital Organs Compared with Moderate Hypothermic Circulatory Arrest in Pig Model |
title_fullStr |
Deep Hypothermic Circulatory Arrest Does Not Show Better Protection for Vital Organs Compared with Moderate Hypothermic Circulatory Arrest in Pig Model |
title_full_unstemmed |
Deep Hypothermic Circulatory Arrest Does Not Show Better Protection for Vital Organs Compared with Moderate Hypothermic Circulatory Arrest in Pig Model |
title_sort |
deep hypothermic circulatory arrest does not show better protection for vital organs compared with moderate hypothermic circulatory arrest in pig model |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2019-01-01 |
description |
Background. Continued debates exist regarding the optimal temperature during hypothermic circulatory arrest in aortic arch repair for patients with type A aortic dissection. This study seeks to examine whether the use of moderate hypothermic circulatory arrest in a pig model provides comparable vital organ protection outcomes to the use of deep hypothermic circulatory arrest. Methods. Thirteen pigs were randomly assigned to 30 minutes of hypothermic circulatory arrest without cerebral perfusion at 15°C (n = 5), 25°C (n = 5), and a control group (n = 3). The changes in standard laboratory tests and capacity for protection against apoptosis in different vital organs were monitored with different temperatures of hypothermic circulatory arrest management in pig model to determine which temperature was optimal for hypothermic circulatory arrest. Results. There were no significant differences in the capacity for protection against apoptosis in vital organs between 2 groups (p > 0.05, respectively). Compared with the moderate hypothermic circulatory arrest group, the deep hypothermic circulatory arrest group had no significant advantages in terms of the biologic parameters of any other organs (p > 0.05). Conclusions. Compared with deep hypothermic circulatory arrest, moderate hypothermic circulatory arrest is a moderate technique that has similar advantages with regard to the levels of biomarkers of injury and capacity for protection against apoptosis in vital organs. |
url |
http://dx.doi.org/10.1155/2019/1420216 |
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doaj-7728006c872d4446b26dc3df5940155e2020-11-25T02:30:15ZengHindawi LimitedBioMed Research International2314-61332314-61412019-01-01201910.1155/2019/14202161420216Deep Hypothermic Circulatory Arrest Does Not Show Better Protection for Vital Organs Compared with Moderate Hypothermic Circulatory Arrest in Pig ModelYang Liu0Zining Wu1Lu Dai2Haiyang Li3Ming Gong4Feng Lan5Xinliang Guan6Hongjia Zhang7Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Lab for Cardiovascular Precision Medicine, Beijing Aortic Disease Center, Cardiovascular Surgery Center, Beijing Engineering Research Center for Vascular Prostheses, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Lab for Cardiovascular Precision Medicine, Beijing Aortic Disease Center, Cardiovascular Surgery Center, Beijing Engineering Research Center for Vascular Prostheses, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Lab for Cardiovascular Precision Medicine, Beijing Aortic Disease Center, Cardiovascular Surgery Center, Beijing Engineering Research Center for Vascular Prostheses, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Lab for Cardiovascular Precision Medicine, Beijing Aortic Disease Center, Cardiovascular Surgery Center, Beijing Engineering Research Center for Vascular Prostheses, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Lab for Cardiovascular Precision Medicine, Beijing Aortic Disease Center, Cardiovascular Surgery Center, Beijing Engineering Research Center for Vascular Prostheses, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Lab for Cardiovascular Precision Medicine, Beijing Aortic Disease Center, Cardiovascular Surgery Center, Beijing Engineering Research Center for Vascular Prostheses, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Lab for Cardiovascular Precision Medicine, Beijing Aortic Disease Center, Cardiovascular Surgery Center, Beijing Engineering Research Center for Vascular Prostheses, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Lab for Cardiovascular Precision Medicine, Beijing Aortic Disease Center, Cardiovascular Surgery Center, Beijing Engineering Research Center for Vascular Prostheses, Beijing, ChinaBackground. Continued debates exist regarding the optimal temperature during hypothermic circulatory arrest in aortic arch repair for patients with type A aortic dissection. This study seeks to examine whether the use of moderate hypothermic circulatory arrest in a pig model provides comparable vital organ protection outcomes to the use of deep hypothermic circulatory arrest. Methods. Thirteen pigs were randomly assigned to 30 minutes of hypothermic circulatory arrest without cerebral perfusion at 15°C (n = 5), 25°C (n = 5), and a control group (n = 3). The changes in standard laboratory tests and capacity for protection against apoptosis in different vital organs were monitored with different temperatures of hypothermic circulatory arrest management in pig model to determine which temperature was optimal for hypothermic circulatory arrest. Results. There were no significant differences in the capacity for protection against apoptosis in vital organs between 2 groups (p > 0.05, respectively). Compared with the moderate hypothermic circulatory arrest group, the deep hypothermic circulatory arrest group had no significant advantages in terms of the biologic parameters of any other organs (p > 0.05). Conclusions. Compared with deep hypothermic circulatory arrest, moderate hypothermic circulatory arrest is a moderate technique that has similar advantages with regard to the levels of biomarkers of injury and capacity for protection against apoptosis in vital organs.http://dx.doi.org/10.1155/2019/1420216 |