Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis
Abstract: Dengue is an important arthropod-borne viral disease in terms of morbidity, mortality, economic impact and challenges in vector control. Benchmarks are expensive, time consuming and require trained personnel. Preventing dengue complications with rapid diagnosis has been based on the testin...
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Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
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doaj-772b0f6b4e114c90aa9e10c8933f26a12020-11-25T02:52:33ZengEscola Nacional de Saúde Pública, Fundação Oswaldo CruzCadernos de Saúde Pública0102-311X1678-446436610.1590/0102-311x00225618S0102-311X2020000602001Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysisVerónica Elizabeth MataCarlos Augusto Ferreira de AndradeSonia Regina Lambert PassosYara Hahr Marques HökerbergLevy Vilas Boas FukuokaSuzana Alves da SilvaAbstract: Dengue is an important arthropod-borne viral disease in terms of morbidity, mortality, economic impact and challenges in vector control. Benchmarks are expensive, time consuming and require trained personnel. Preventing dengue complications with rapid diagnosis has been based on the testing of easy-to-perform optimized immunochromatographic methods (ICT). This is a systematic meta-analysis review of the diagnostic accuracy of IgA, NS1, IgM and/or IgG ICT studies in suspected cases of acute or convalescent dengue, using a combination of RT-PCR, ELISA NS1, IgM IgG or viral isolation as a reference standard. This protocol was registered in PROSPERO (CRD42014009885). Two pairs of reviewers searched the PubMed, BIREME, Science Direct, Scopus, Web of Science, Ovid MEDLINE JBrigs, SCIRUS and EMBASE databases, selected, extracted, and quality-assessed by QUADAS 2. Of 3,783 studies, we selected 57, of which 40 in meta-analyses according to the analyte tested, with high heterogeneity (I2 > 90%), as expected for diagnostic tests. We detected higher pooled sensitivity in acute phase IgA (92.8%) with excellent (90%) specificity. ICT meta-analysis with NS1/IgM/IgG showed 91% sensitivity and 96% specificity. Poorer screening performance was for IgM/IgG ICT (sensitivity = 56%). Thus, the studies with NS1/IgM/IgG ICT showed the best combined performance in the acute phase of the disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2020000602001&lng=en&tlng=endenguediagnósticosensibilidade e especificidaderevisão sistemáticametanálise |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Verónica Elizabeth Mata Carlos Augusto Ferreira de Andrade Sonia Regina Lambert Passos Yara Hahr Marques Hökerberg Levy Vilas Boas Fukuoka Suzana Alves da Silva |
spellingShingle |
Verónica Elizabeth Mata Carlos Augusto Ferreira de Andrade Sonia Regina Lambert Passos Yara Hahr Marques Hökerberg Levy Vilas Boas Fukuoka Suzana Alves da Silva Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis Cadernos de Saúde Pública dengue diagnóstico sensibilidade e especificidade revisão sistemática metanálise |
author_facet |
Verónica Elizabeth Mata Carlos Augusto Ferreira de Andrade Sonia Regina Lambert Passos Yara Hahr Marques Hökerberg Levy Vilas Boas Fukuoka Suzana Alves da Silva |
author_sort |
Verónica Elizabeth Mata |
title |
Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis |
title_short |
Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis |
title_full |
Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis |
title_fullStr |
Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis |
title_full_unstemmed |
Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis |
title_sort |
rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis |
publisher |
Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz |
series |
Cadernos de Saúde Pública |
issn |
0102-311X 1678-4464 |
description |
Abstract: Dengue is an important arthropod-borne viral disease in terms of morbidity, mortality, economic impact and challenges in vector control. Benchmarks are expensive, time consuming and require trained personnel. Preventing dengue complications with rapid diagnosis has been based on the testing of easy-to-perform optimized immunochromatographic methods (ICT). This is a systematic meta-analysis review of the diagnostic accuracy of IgA, NS1, IgM and/or IgG ICT studies in suspected cases of acute or convalescent dengue, using a combination of RT-PCR, ELISA NS1, IgM IgG or viral isolation as a reference standard. This protocol was registered in PROSPERO (CRD42014009885). Two pairs of reviewers searched the PubMed, BIREME, Science Direct, Scopus, Web of Science, Ovid MEDLINE JBrigs, SCIRUS and EMBASE databases, selected, extracted, and quality-assessed by QUADAS 2. Of 3,783 studies, we selected 57, of which 40 in meta-analyses according to the analyte tested, with high heterogeneity (I2 > 90%), as expected for diagnostic tests. We detected higher pooled sensitivity in acute phase IgA (92.8%) with excellent (90%) specificity. ICT meta-analysis with NS1/IgM/IgG showed 91% sensitivity and 96% specificity. Poorer screening performance was for IgM/IgG ICT (sensitivity = 56%). Thus, the studies with NS1/IgM/IgG ICT showed the best combined performance in the acute phase of the disease. |
topic |
dengue diagnóstico sensibilidade e especificidade revisão sistemática metanálise |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2020000602001&lng=en&tlng=en |
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