Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten
As a Mongolian native medicine and Ewenki folk medicinal plant, Gentianella acuta has been widely used for the treatment of diarrhea, hepatitis, arrhythmia, and coronary heart disease. In the course of investigating efficacy compounds to treat diarrhea using a mouse isolated intestine tissue model,...
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doaj-772c074e595d45caacbbe3a7011fbf512020-11-25T02:31:02ZengMDPI AGMolecules1420-30492017-08-01228130910.3390/molecules22081309molecules22081309Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) HultenZhijuan Ding0Yanxia Liu1Jingya Ruan2Shengcai Yang3Haiyang Yu4Meiling Chen5Yi Zhang6Tao Wang7Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, ChinaTianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, ChinaTianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, ChinaTianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, ChinaTianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, ChinaTianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, ChinaTianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, ChinaTianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, ChinaAs a Mongolian native medicine and Ewenki folk medicinal plant, Gentianella acuta has been widely used for the treatment of diarrhea, hepatitis, arrhythmia, and coronary heart disease. In the course of investigating efficacy compounds to treat diarrhea using a mouse isolated intestine tissue model, we found 70% EtOH extract of G. acuta whole plants had an inhibitory effect on intestine contraction tension. Here, nineteen constituents, including five new compounds, named as gentiiridosides A (1), B (2), gentilignanoside A (3), (1R)-2,2,3-trimethyl-4-hydroxymethylcyclopent-3-ene-1-methyl-O-β-d-glucopyranoside (4), and (3Z)-3-hexene-1,5-diol 1-O-α-l-arabinopyranosyl(1→6)-β-d-glucopyranoside (5) were obtained from it. The structures of them were elucidated by chemical and spectroscopic methods. Furthermore, the inhibitory effects on motility of mouse isolated intestine tissue of the above mentioned compounds and other thirteen iridoid- and secoiridoid-type monoterpenes (7–10, 13–16, 18, 19, 21, 22, and 25) previously obtained in the plant were analyzed. As results, new compound 5, some secoiridoid-type monoterpenes 7, 10, 12–14, 16, and 17, as well as 7-O-9′-type lignans 31 and 32 displayed significant inhibitory effect on contraction tension at 40 μM.https://www.mdpi.com/1420-3049/22/8/1309Gentianella acuta (Michx.) Hultenlignaniridoid- and secoiridoid-type monoterpeneintestine motilitymouse isolated intestine tissue |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhijuan Ding Yanxia Liu Jingya Ruan Shengcai Yang Haiyang Yu Meiling Chen Yi Zhang Tao Wang |
spellingShingle |
Zhijuan Ding Yanxia Liu Jingya Ruan Shengcai Yang Haiyang Yu Meiling Chen Yi Zhang Tao Wang Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten Molecules Gentianella acuta (Michx.) Hulten lignan iridoid- and secoiridoid-type monoterpene intestine motility mouse isolated intestine tissue |
author_facet |
Zhijuan Ding Yanxia Liu Jingya Ruan Shengcai Yang Haiyang Yu Meiling Chen Yi Zhang Tao Wang |
author_sort |
Zhijuan Ding |
title |
Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten |
title_short |
Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten |
title_full |
Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten |
title_fullStr |
Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten |
title_full_unstemmed |
Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten |
title_sort |
bioactive constituents from the whole plants of gentianella acuta (michx.) hulten |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2017-08-01 |
description |
As a Mongolian native medicine and Ewenki folk medicinal plant, Gentianella acuta has been widely used for the treatment of diarrhea, hepatitis, arrhythmia, and coronary heart disease. In the course of investigating efficacy compounds to treat diarrhea using a mouse isolated intestine tissue model, we found 70% EtOH extract of G. acuta whole plants had an inhibitory effect on intestine contraction tension. Here, nineteen constituents, including five new compounds, named as gentiiridosides A (1), B (2), gentilignanoside A (3), (1R)-2,2,3-trimethyl-4-hydroxymethylcyclopent-3-ene-1-methyl-O-β-d-glucopyranoside (4), and (3Z)-3-hexene-1,5-diol 1-O-α-l-arabinopyranosyl(1→6)-β-d-glucopyranoside (5) were obtained from it. The structures of them were elucidated by chemical and spectroscopic methods. Furthermore, the inhibitory effects on motility of mouse isolated intestine tissue of the above mentioned compounds and other thirteen iridoid- and secoiridoid-type monoterpenes (7–10, 13–16, 18, 19, 21, 22, and 25) previously obtained in the plant were analyzed. As results, new compound 5, some secoiridoid-type monoterpenes 7, 10, 12–14, 16, and 17, as well as 7-O-9′-type lignans 31 and 32 displayed significant inhibitory effect on contraction tension at 40 μM. |
topic |
Gentianella acuta (Michx.) Hulten lignan iridoid- and secoiridoid-type monoterpene intestine motility mouse isolated intestine tissue |
url |
https://www.mdpi.com/1420-3049/22/8/1309 |
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