p53 p.Pro72Arg (rs1042522) and Mouse Double Minute 2 (MDM2) Single-Nucleotide Polymorphism (SNP) 309 Variants and Their Interaction in Chronic Lymphocytic Leukemia(CLL): A Survey in CLL Patients from Western Iran

p53 p.Pro72Arg (rs1042522) and Mouse Double Minute 2 (MDM2) Single-Nucleotide Polymorphism (SNP) 309 Variants and Their Interaction in Chronic Lymphocytic Leukemia(CLL): A Survey in CLL Patients from Western Iran

Background: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. The MDM2 and p53 are interacting proteins that play crucial roles in cell biology. Genetic variations of p53 and MDM2 (p53 codon 72 and MDM2 SNP30) have been identified in many cancers including CLL. Materials...

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Bibliographic Details
Main Authors: Nazanin Jalilian, Yosra Maleki, Ebrahim Shakiba, Mozafar Aznab, Ziba Rahimi, Mehdi salimi, Zohreh Rahimi
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2021-07-01
Series:International Journal of Hematology-Oncology and Stem Cell Research
Subjects:
CLL, p53, Mouse double minute 2 (MDM2), gene polymorphism, gene-gene interaction
Online Access:https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1256

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