Glycyrrhizic Acid Can Attenuate Metabolic Deviations Caused by a High-Sucrose Diet without Causing Water Retention in Male Sprague-Dawley Rats
Glycyrrhizic acid (GA) ameliorates many components of the metabolic syndrome, but its potential therapeutic use is marred by edema caused by inhibition of renal 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2). We assessed whether 100 mg/kg per day GA administered orally could promote metabolic benefit...
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doaj-77393c72a41d4679be16886705d8f33a2020-11-24T22:00:04ZengMDPI AGNutrients2072-66432014-11-016114856487110.3390/nu6114856nu6114856Glycyrrhizic Acid Can Attenuate Metabolic Deviations Caused by a High-Sucrose Diet without Causing Water Retention in Male Sprague-Dawley RatsHamish Alexander Fernando0Chanchal Chandramouli1Dayang Rosli2Yi Lyn Lam3Sheau Ting Yong4Hui Ping Yaw5So Ha Ton6Khalid Abdul Kadir7Amanda Sainsbury8School of Science, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 46150, MalaysiaSchool of Science, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 46150, MalaysiaSchool of Science, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 46150, MalaysiaSchool of Science, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 46150, MalaysiaSchool of Science, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 46150, MalaysiaSchool of Science, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 46150, MalaysiaSchool of Science, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 46150, MalaysiaSchool of Medicine and Health Sciences, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 46150, MalaysiaThe Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, Sydney Medical School, The University of Sydney, Camperdown, New South Wales 2006, AustraliaGlycyrrhizic acid (GA) ameliorates many components of the metabolic syndrome, but its potential therapeutic use is marred by edema caused by inhibition of renal 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2). We assessed whether 100 mg/kg per day GA administered orally could promote metabolic benefits without causing edema in rats fed on a high-sucrose diet. Groups of eight male rats were fed on one of three diets for 28 days: normal diet, a high-sucrose diet, or a high-sucrose diet supplemented with GA. Rats were then culled and renal 11β-HSD2 activity, as well as serum sodium, potassium, angiotensin II and leptin levels were determined. Histological analyses were performed to assess changes in adipocyte size in visceral and subcutaneous depots, as well as hepatic and renal tissue morphology. This dosing paradigm of GA attenuated the increases in serum leptin levels and visceral, but not subcutaneous adipocyte size caused by the high-sucrose diet. Although GA decreased renal 11β-HSD2 activity, it did not affect serum electrolyte or angiotensin II levels, indicating no onset of edema. Furthermore, there were no apparent morphological changes in the liver or kidney, indicating no toxicity. In conclusion, it is possible to reap metabolic benefits of GA without edema using the current dosage and treatment time.http://www.mdpi.com/2072-6643/6/11/4856glycyrrhizic acidmetabolic syndromehigh-sucrose diet11β-HSD2side effectsedemaangiotensin IIelectrolytes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hamish Alexander Fernando Chanchal Chandramouli Dayang Rosli Yi Lyn Lam Sheau Ting Yong Hui Ping Yaw So Ha Ton Khalid Abdul Kadir Amanda Sainsbury |
spellingShingle |
Hamish Alexander Fernando Chanchal Chandramouli Dayang Rosli Yi Lyn Lam Sheau Ting Yong Hui Ping Yaw So Ha Ton Khalid Abdul Kadir Amanda Sainsbury Glycyrrhizic Acid Can Attenuate Metabolic Deviations Caused by a High-Sucrose Diet without Causing Water Retention in Male Sprague-Dawley Rats Nutrients glycyrrhizic acid metabolic syndrome high-sucrose diet 11β-HSD2 side effects edema angiotensin II electrolytes |
author_facet |
Hamish Alexander Fernando Chanchal Chandramouli Dayang Rosli Yi Lyn Lam Sheau Ting Yong Hui Ping Yaw So Ha Ton Khalid Abdul Kadir Amanda Sainsbury |
author_sort |
Hamish Alexander Fernando |
title |
Glycyrrhizic Acid Can Attenuate Metabolic Deviations Caused by a High-Sucrose Diet without Causing Water Retention in Male Sprague-Dawley Rats |
title_short |
Glycyrrhizic Acid Can Attenuate Metabolic Deviations Caused by a High-Sucrose Diet without Causing Water Retention in Male Sprague-Dawley Rats |
title_full |
Glycyrrhizic Acid Can Attenuate Metabolic Deviations Caused by a High-Sucrose Diet without Causing Water Retention in Male Sprague-Dawley Rats |
title_fullStr |
Glycyrrhizic Acid Can Attenuate Metabolic Deviations Caused by a High-Sucrose Diet without Causing Water Retention in Male Sprague-Dawley Rats |
title_full_unstemmed |
Glycyrrhizic Acid Can Attenuate Metabolic Deviations Caused by a High-Sucrose Diet without Causing Water Retention in Male Sprague-Dawley Rats |
title_sort |
glycyrrhizic acid can attenuate metabolic deviations caused by a high-sucrose diet without causing water retention in male sprague-dawley rats |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2014-11-01 |
description |
Glycyrrhizic acid (GA) ameliorates many components of the metabolic syndrome, but its potential therapeutic use is marred by edema caused by inhibition of renal 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2). We assessed whether 100 mg/kg per day GA administered orally could promote metabolic benefits without causing edema in rats fed on a high-sucrose diet. Groups of eight male rats were fed on one of three diets for 28 days: normal diet, a high-sucrose diet, or a high-sucrose diet supplemented with GA. Rats were then culled and renal 11β-HSD2 activity, as well as serum sodium, potassium, angiotensin II and leptin levels were determined. Histological analyses were performed to assess changes in adipocyte size in visceral and subcutaneous depots, as well as hepatic and renal tissue morphology. This dosing paradigm of GA attenuated the increases in serum leptin levels and visceral, but not subcutaneous adipocyte size caused by the high-sucrose diet. Although GA decreased renal 11β-HSD2 activity, it did not affect serum electrolyte or angiotensin II levels, indicating no onset of edema. Furthermore, there were no apparent morphological changes in the liver or kidney, indicating no toxicity. In conclusion, it is possible to reap metabolic benefits of GA without edema using the current dosage and treatment time. |
topic |
glycyrrhizic acid metabolic syndrome high-sucrose diet 11β-HSD2 side effects edema angiotensin II electrolytes |
url |
http://www.mdpi.com/2072-6643/6/11/4856 |
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