Chronology of motor-mediated microtubule streaming
We introduce a filament-based simulation model for coarse-grained, effective motor-mediated interaction between microtubule pairs to study the time-scales that compose cytoplasmic streaming. We characterise microtubule dynamics in two-dimensional systems by chronologically arranging five distinct pr...
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doaj-77435194bb45477ba9949cfc6884970d2021-05-05T17:17:18ZengeLife Sciences Publications LtdeLife2050-084X2019-01-01810.7554/eLife.39694Chronology of motor-mediated microtubule streamingArvind Ravichandran0https://orcid.org/0000-0001-6247-5229Özer Duman1Masoud Hoore2https://orcid.org/0000-0003-1442-4739Guglielmo Saggiorato3Gerard A Vliegenthart4https://orcid.org/0000-0003-2459-8652Thorsten Auth5https://orcid.org/0000-0002-6618-2316Gerhard Gompper6https://orcid.org/0000-0002-8904-0986Theoretical Soft Matter and Biophysics, Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Jülich, Jülich, GermanyTheoretical Soft Matter and Biophysics, Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Jülich, Jülich, GermanyTheoretical Soft Matter and Biophysics, Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Jülich, Jülich, GermanyTheoretical Soft Matter and Biophysics, Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Jülich, Jülich, GermanyTheoretical Soft Matter and Biophysics, Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Jülich, Jülich, GermanyTheoretical Soft Matter and Biophysics, Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Jülich, Jülich, GermanyTheoretical Soft Matter and Biophysics, Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Jülich, Jülich, GermanyWe introduce a filament-based simulation model for coarse-grained, effective motor-mediated interaction between microtubule pairs to study the time-scales that compose cytoplasmic streaming. We characterise microtubule dynamics in two-dimensional systems by chronologically arranging five distinct processes of varying duration that make up streaming, from microtubule pairs to collective dynamics. The structures found were polarity sorted due to the propulsion of antialigned microtubules. This also gave rise to the formation of large polar-aligned domains, and streaming at the domain boundaries. Correlation functions, mean squared displacements, and velocity distributions reveal a cascade of processes ultimately leading to microtubule streaming and advection, spanning multiple microtubule lengths. The characteristic times for the processes extend over three orders of magnitude from fast single-microtubule processes to slow collective processes. Our approach can be used to directly test the importance of molecular components, such as motors and crosslinking proteins between microtubules, on the collective dynamics at cellular scale.https://elifesciences.org/articles/39694computer simulationsmicrotubulesmolecular motorskinesincytoskeletal streaming |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Arvind Ravichandran Özer Duman Masoud Hoore Guglielmo Saggiorato Gerard A Vliegenthart Thorsten Auth Gerhard Gompper |
spellingShingle |
Arvind Ravichandran Özer Duman Masoud Hoore Guglielmo Saggiorato Gerard A Vliegenthart Thorsten Auth Gerhard Gompper Chronology of motor-mediated microtubule streaming eLife computer simulations microtubules molecular motors kinesin cytoskeletal streaming |
author_facet |
Arvind Ravichandran Özer Duman Masoud Hoore Guglielmo Saggiorato Gerard A Vliegenthart Thorsten Auth Gerhard Gompper |
author_sort |
Arvind Ravichandran |
title |
Chronology of motor-mediated microtubule streaming |
title_short |
Chronology of motor-mediated microtubule streaming |
title_full |
Chronology of motor-mediated microtubule streaming |
title_fullStr |
Chronology of motor-mediated microtubule streaming |
title_full_unstemmed |
Chronology of motor-mediated microtubule streaming |
title_sort |
chronology of motor-mediated microtubule streaming |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2019-01-01 |
description |
We introduce a filament-based simulation model for coarse-grained, effective motor-mediated interaction between microtubule pairs to study the time-scales that compose cytoplasmic streaming. We characterise microtubule dynamics in two-dimensional systems by chronologically arranging five distinct processes of varying duration that make up streaming, from microtubule pairs to collective dynamics. The structures found were polarity sorted due to the propulsion of antialigned microtubules. This also gave rise to the formation of large polar-aligned domains, and streaming at the domain boundaries. Correlation functions, mean squared displacements, and velocity distributions reveal a cascade of processes ultimately leading to microtubule streaming and advection, spanning multiple microtubule lengths. The characteristic times for the processes extend over three orders of magnitude from fast single-microtubule processes to slow collective processes. Our approach can be used to directly test the importance of molecular components, such as motors and crosslinking proteins between microtubules, on the collective dynamics at cellular scale. |
topic |
computer simulations microtubules molecular motors kinesin cytoskeletal streaming |
url |
https://elifesciences.org/articles/39694 |
work_keys_str_mv |
AT arvindravichandran chronologyofmotormediatedmicrotubulestreaming AT ozerduman chronologyofmotormediatedmicrotubulestreaming AT masoudhoore chronologyofmotormediatedmicrotubulestreaming AT guglielmosaggiorato chronologyofmotormediatedmicrotubulestreaming AT gerardavliegenthart chronologyofmotormediatedmicrotubulestreaming AT thorstenauth chronologyofmotormediatedmicrotubulestreaming AT gerhardgompper chronologyofmotormediatedmicrotubulestreaming |
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