Using Digitally Reconstructed Radiographs from MRI (MRI-DRR) to Localize Pelvic Lymph Nodes on 2D X-ray Simulator-Based Brachytherapy Treatment Planning
Purpose: Many of the available brachytherapy treatment planning systems in developing countries are not equipped with CT (or MRI) simulator; therefore, 3D treatment planning cannot be performed. In this project a new procedure has been introduced for utilizing the 2D digitally reconstructed radiogr...
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Tehran University of Medical Sciences
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doaj-77469260087348cb907f89bb45f61d712020-11-25T04:08:32ZengTehran University of Medical SciencesFrontiers in Biomedical Technologies2345-58372014-03-0111Using Digitally Reconstructed Radiographs from MRI (MRI-DRR) to Localize Pelvic Lymph Nodes on 2D X-ray Simulator-Based Brachytherapy Treatment PlanningMohammad-Ali Oghabian0Reza Riazi1Esmail Parsai2Mehdi Aghili3Ramin Jaberi4Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Iran.Research Center for Molecular and Cellular Imaging (RCMCI), Tehran University of Medical Sciences, Iran.University of Toledo, College of Medicine, USA.Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Iran.Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Iran. Purpose: Many of the available brachytherapy treatment planning systems in developing countries are not equipped with CT (or MRI) simulator; therefore, 3D treatment planning cannot be performed. In this project a new procedure has been introduced for utilizing the 2D digitally reconstructed radiograph from MRI images in brachytherapy treatment planning. This procedure enables us to localize the tumor volume and delineate the extent of critical structures in vicinity of tumor volume. Methods: Pelvic lymph node chain position was delineated from transverse MRI images, and transferred into Digitally Reconstructed Radiograph (DRR) and then onto the X-ray images obtained from conventional simulator unit. These images were then imported to Brachytherapy treatment planning system to evaluate the dose to be applied to these organs in cervix Brachytherapy. The accuracy of the matching process was evaluated by phantom study, having known 3D geometric information and landmark assertion. Results: The statistical variations obtained from distance mismatch in phantom and patient studies were in the range of clinically applicable error of registration (< 2mm). The results showed a large variation of the nodal dose when dose calculation is performed based on point B dose which is the geometrical reference point for calculating the dose to the pelvic lymphatic system. The result also shows that the dose to point B is usually underestimated to represent external iliac maximum dose, and overestimated for representation of external iliac minimum dose. Conclusion: The results indicated that the DRR images can produce comparable accuracies in tumor localization reported in 3D MRI or CT based treatment planning procedures. Therefore, this technique could be used as a feasible approach where a 3D treatment planning is not available. https://fbt.tums.ac.ir/index.php/fbt/article/view/18BrachytherapyRegistrationCervixDRRSimulation. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad-Ali Oghabian Reza Riazi Esmail Parsai Mehdi Aghili Ramin Jaberi |
spellingShingle |
Mohammad-Ali Oghabian Reza Riazi Esmail Parsai Mehdi Aghili Ramin Jaberi Using Digitally Reconstructed Radiographs from MRI (MRI-DRR) to Localize Pelvic Lymph Nodes on 2D X-ray Simulator-Based Brachytherapy Treatment Planning Frontiers in Biomedical Technologies Brachytherapy Registration Cervix DRR Simulation. |
author_facet |
Mohammad-Ali Oghabian Reza Riazi Esmail Parsai Mehdi Aghili Ramin Jaberi |
author_sort |
Mohammad-Ali Oghabian |
title |
Using Digitally Reconstructed Radiographs from MRI (MRI-DRR) to Localize Pelvic Lymph Nodes on 2D X-ray Simulator-Based Brachytherapy Treatment Planning |
title_short |
Using Digitally Reconstructed Radiographs from MRI (MRI-DRR) to Localize Pelvic Lymph Nodes on 2D X-ray Simulator-Based Brachytherapy Treatment Planning |
title_full |
Using Digitally Reconstructed Radiographs from MRI (MRI-DRR) to Localize Pelvic Lymph Nodes on 2D X-ray Simulator-Based Brachytherapy Treatment Planning |
title_fullStr |
Using Digitally Reconstructed Radiographs from MRI (MRI-DRR) to Localize Pelvic Lymph Nodes on 2D X-ray Simulator-Based Brachytherapy Treatment Planning |
title_full_unstemmed |
Using Digitally Reconstructed Radiographs from MRI (MRI-DRR) to Localize Pelvic Lymph Nodes on 2D X-ray Simulator-Based Brachytherapy Treatment Planning |
title_sort |
using digitally reconstructed radiographs from mri (mri-drr) to localize pelvic lymph nodes on 2d x-ray simulator-based brachytherapy treatment planning |
publisher |
Tehran University of Medical Sciences |
series |
Frontiers in Biomedical Technologies |
issn |
2345-5837 |
publishDate |
2014-03-01 |
description |
Purpose: Many of the available brachytherapy treatment planning systems in developing countries are not equipped with CT (or MRI) simulator; therefore, 3D treatment planning cannot be performed. In this project a new procedure has been introduced for utilizing the 2D digitally reconstructed radiograph from MRI images in brachytherapy treatment planning. This procedure enables us to localize the tumor volume and delineate the extent of critical structures in vicinity of tumor volume.
Methods: Pelvic lymph node chain position was delineated from transverse MRI images, and transferred into Digitally Reconstructed Radiograph (DRR) and then onto the X-ray images obtained from conventional simulator unit. These images were then imported to Brachytherapy treatment planning system to evaluate the dose to be applied to these organs in cervix Brachytherapy. The accuracy of the matching process was evaluated by phantom study, having known 3D geometric information and landmark assertion.
Results: The statistical variations obtained from distance mismatch in phantom and patient studies were in the range of clinically applicable error of registration (< 2mm). The results showed a large variation of the nodal dose when dose calculation is performed based on point B dose which is the geometrical reference point for calculating the dose to the pelvic lymphatic system. The result also shows that the dose to point B is usually underestimated to represent external iliac maximum dose, and overestimated for representation of external iliac minimum dose.
Conclusion: The results indicated that the DRR images can produce comparable accuracies in tumor localization reported in 3D MRI or CT based treatment planning procedures. Therefore, this technique could be used as a feasible approach where a 3D treatment planning is not available.
|
topic |
Brachytherapy Registration Cervix DRR Simulation. |
url |
https://fbt.tums.ac.ir/index.php/fbt/article/view/18 |
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