Cytosine-Rich DNA Fragments Covalently Bound to Carbon Nanotube as Factors Triggering Doxorubicin Release at Acidic pH. A Molecular Dynamics Study

Cytosine-Rich DNA Fragments Covalently Bound to Carbon Nanotube as Factors Triggering Doxorubicin Release at Acidic pH. A Molecular Dynamics Study

This works deals with analysis of properties of a carbon nanotube, the tips of which were functionalized by short cytosine-rich fragments of ssDNA. That object is aimed to work as a platform for storage and controlled release of doxorubicin in response to pH changes. We found that at neutral pH, dox...

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Bibliographic Details
Main Authors: Pawel Wolski, Krzysztof Nieszporek, Tomasz Panczyk
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
carbon nanotube
i-motif
cytosine-rich DNA
doxorubicin
drug delivery
pH change
Online Access:https://www.mdpi.com/1422-0067/22/16/8466

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