The Expression Patterns and Roles of Lysyl Oxidases in Aortic Dissection

The Expression Patterns and Roles of Lysyl Oxidases in Aortic Dissection

Background: Lysyl oxidases (LOXs), including LOX, LOXL1, LOXL2, LOXL3, and LOXL4, catalyze the formation of a cross-link between elastin (ELN) and collagen. Multiple LOX mutations have been shown to be associated with the occurrence of aortic dissection (AD) in humans, and LOX-knockout mice died dur...

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Bibliographic Details
Main Authors: Xin Yi, Yi Zhou, Yue Chen, Xin Feng, Chang Liu, Ding-Sheng Jiang, Jing Geng, Xiaoyan Li, Xuejun Jiang, Ze-Min Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
lysyl oxidase
aortic dissection
LOX
MMP2
metformin
losartan
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.692856/full

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