Pulmonary Macrophage and Dendritic Cell Responses to Cryptococcus neoformans
The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in immune compromised individuals. This pathogen is typically acquired via inhalation, and enters the respiratory tract. Innate immune cells such as macrophages and dendritic cells (DCs) are the first host cells that e...
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2020-02-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2020.00037/full |
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doaj-775badbb8e1140f1b79a90b13a852db52020-11-25T01:13:27ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-02-011010.3389/fcimb.2020.00037502238Pulmonary Macrophage and Dendritic Cell Responses to Cryptococcus neoformansBenjamin N. NelsonAshlee N. HawkinsKaren L. WozniakThe fungal pathogen Cryptococcus neoformans can cause life-threatening infections in immune compromised individuals. This pathogen is typically acquired via inhalation, and enters the respiratory tract. Innate immune cells such as macrophages and dendritic cells (DCs) are the first host cells that encounter C. neoformans, and the interactions between Cryptococcus and innate immune cells play a critical role in the progression of disease. Cryptococcus possesses several virulence factors and evasion strategies to prevent its killing and destruction by pulmonary phagocytes, but these phagocytic cells can also contribute to anti-cryptococcal responses. This review will focus on the interactions between Cryptococcus and primary macrophages and dendritic cells (DCs), dealing specifically with the cryptococcal/pulmonary cell interface.https://www.frontiersin.org/article/10.3389/fcimb.2020.00037/fullCryptococcuspulmonary macrophagespulmonary dendritic cellprimary phagocytesinnate phagocytesmacrophage subsets |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Benjamin N. Nelson Ashlee N. Hawkins Karen L. Wozniak |
spellingShingle |
Benjamin N. Nelson Ashlee N. Hawkins Karen L. Wozniak Pulmonary Macrophage and Dendritic Cell Responses to Cryptococcus neoformans Frontiers in Cellular and Infection Microbiology Cryptococcus pulmonary macrophages pulmonary dendritic cell primary phagocytes innate phagocytes macrophage subsets |
author_facet |
Benjamin N. Nelson Ashlee N. Hawkins Karen L. Wozniak |
author_sort |
Benjamin N. Nelson |
title |
Pulmonary Macrophage and Dendritic Cell Responses to Cryptococcus neoformans |
title_short |
Pulmonary Macrophage and Dendritic Cell Responses to Cryptococcus neoformans |
title_full |
Pulmonary Macrophage and Dendritic Cell Responses to Cryptococcus neoformans |
title_fullStr |
Pulmonary Macrophage and Dendritic Cell Responses to Cryptococcus neoformans |
title_full_unstemmed |
Pulmonary Macrophage and Dendritic Cell Responses to Cryptococcus neoformans |
title_sort |
pulmonary macrophage and dendritic cell responses to cryptococcus neoformans |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2020-02-01 |
description |
The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in immune compromised individuals. This pathogen is typically acquired via inhalation, and enters the respiratory tract. Innate immune cells such as macrophages and dendritic cells (DCs) are the first host cells that encounter C. neoformans, and the interactions between Cryptococcus and innate immune cells play a critical role in the progression of disease. Cryptococcus possesses several virulence factors and evasion strategies to prevent its killing and destruction by pulmonary phagocytes, but these phagocytic cells can also contribute to anti-cryptococcal responses. This review will focus on the interactions between Cryptococcus and primary macrophages and dendritic cells (DCs), dealing specifically with the cryptococcal/pulmonary cell interface. |
topic |
Cryptococcus pulmonary macrophages pulmonary dendritic cell primary phagocytes innate phagocytes macrophage subsets |
url |
https://www.frontiersin.org/article/10.3389/fcimb.2020.00037/full |
work_keys_str_mv |
AT benjaminnnelson pulmonarymacrophageanddendriticcellresponsestocryptococcusneoformans AT ashleenhawkins pulmonarymacrophageanddendriticcellresponsestocryptococcusneoformans AT karenlwozniak pulmonarymacrophageanddendriticcellresponsestocryptococcusneoformans |
_version_ |
1725162244695654400 |