Changes in Gut Hormones After Roux en Y Gastric bypass, Sleeve Gastrectomy, and Adjustable Gastric Banding

• Main Authors: Miroslav Ilić, Fuad Pašić, Lora Kirigin, Gorana Mirošević, Miroslav Bekavac Bešlin
• Format: Article
• Language: English
• Published: VBZ 2015-12-01
• Series: Endocrine Oncology and Metabolism
• Subjects: bariatric surgery; gut hormones; changes; weight loss
• Online Access: http://eom.hdeo.eu/wp-content/uploads/2017/02/vol1-iss1-3Ilic.pdf

The obesity epidemic has burdened healthcare systems worldwide. Bariatric surgery is currently the most effective method for long-term weight loss in obese adults, but the exact mechanism of weight loss is poorly understood. Bariatric procedures were initially classified by their presumed mechanism of action into restrictive, malabsoptive, or mixed procedures; however, due to recent advancements in the field of neuroendocrinology, hormones are increasing being recognized as important regulators of satiation, hunger, and energy expenditure. Studies examining changes in gut hormones following bariatric surgery have yielded conflicting results and the relationship between these hormones and weight loss is nothing but clear. This review will summarize the effect of Roux en Y gastric bypass, sleeve gastrectomy and adjustable gastric banding on various gut hormones including ghrelin, cholecystokinin, glucagon-like polypeptide-1, peptide YY3, and pancreatic polypeptide. Furthermore, the relationship between these hormones and weight loss will be examined.