Markers of Angiogenesis in Ovarian Cancer
Tumor development and progression are inherently dependent on the process of angiogenesis. Recently, anti-angiogenic therapy has started to show promise as an effective treatment strategy in many solid tumors including ovarian carcinoma. Unfortunately, lack of effective biomarkers presents a challen...
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Hindawi Limited
2007-01-01
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Series: | Disease Markers |
Online Access: | http://dx.doi.org/10.1155/2007/257602 |
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doaj-7768a84d885742e4b9855c7ed5220ce12020-11-25T00:07:13ZengHindawi LimitedDisease Markers0278-02401875-86302007-01-01235-641943110.1155/2007/257602Markers of Angiogenesis in Ovarian CancerWilliam M. Merritt0Anil K. Sood1Department of Gynecologic Oncology, U.T. M.D. Anderson Cancer Center, Unit 1362, P.O. Box 301439, Houston TX 77230-1439, USADepartment of Gynecologic Oncology, U.T. M.D. Anderson Cancer Center, Unit 1362, P.O. Box 301439, Houston TX 77230-1439, USATumor development and progression are inherently dependent on the process of angiogenesis. Recently, anti-angiogenic therapy has started to show promise as an effective treatment strategy in many solid tumors including ovarian carcinoma. Unfortunately, lack of effective biomarkers presents a challenge for oncologists in treatment planning as well as monitoring response of new anti-vascular agents. Previously, quantification of angiogenesis by microvessel density analysis provided useful prognostic information, however, its utility following anti-angiogenic therapy remains to be determined. Moreover, since secreted cytokines play an active part in angiogenesis by mediating neovascularization in tumors, investigations have focused on their potential role to serve as candidate biomarkers of disease detection, prognosis, and treatment response. In this article, we review the role of key angiogenesis markers as potential biomarkers in ovarian carcinoma.http://dx.doi.org/10.1155/2007/257602 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
William M. Merritt Anil K. Sood |
spellingShingle |
William M. Merritt Anil K. Sood Markers of Angiogenesis in Ovarian Cancer Disease Markers |
author_facet |
William M. Merritt Anil K. Sood |
author_sort |
William M. Merritt |
title |
Markers of Angiogenesis in Ovarian Cancer |
title_short |
Markers of Angiogenesis in Ovarian Cancer |
title_full |
Markers of Angiogenesis in Ovarian Cancer |
title_fullStr |
Markers of Angiogenesis in Ovarian Cancer |
title_full_unstemmed |
Markers of Angiogenesis in Ovarian Cancer |
title_sort |
markers of angiogenesis in ovarian cancer |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2007-01-01 |
description |
Tumor development and progression are inherently dependent on the process of angiogenesis. Recently, anti-angiogenic therapy has started to show promise as an effective treatment strategy in many solid tumors including ovarian carcinoma. Unfortunately, lack of effective biomarkers presents a challenge for oncologists in treatment planning as well as monitoring response of new anti-vascular agents. Previously, quantification of angiogenesis by microvessel density analysis provided useful prognostic information, however, its utility following anti-angiogenic therapy remains to be determined. Moreover, since secreted cytokines play an active part in angiogenesis by mediating neovascularization in tumors, investigations have focused on their potential role to serve as candidate biomarkers of disease detection, prognosis, and treatment response. In this article, we review the role of key angiogenesis markers as potential biomarkers in ovarian carcinoma. |
url |
http://dx.doi.org/10.1155/2007/257602 |
work_keys_str_mv |
AT williammmerritt markersofangiogenesisinovariancancer AT anilksood markersofangiogenesisinovariancancer |
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