High prevalence of diabetes and abnormal glucose tolerance in Thai women with previous gestational diabetes mellitus
Aim: To determine the prevalence of and risk factors for abnormal glucose tolerance (AGT) in previous gestational diabetes mellitus (pGDM) women. Methods: 100 pGDM women randomly selected from the database of the Department of Obstetrics/Gynecology. 75 g-OGTT were performed in subjects without known...
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doaj-776edd0608814aa58cdba1bbfc3ef7012020-11-25T02:00:07ZengElsevierJournal of Clinical & Translational Endocrinology2214-62372017-09-0192124High prevalence of diabetes and abnormal glucose tolerance in Thai women with previous gestational diabetes mellitusSirisawat Wanthong0Raweewan Lertwattanarak1Prasert Sunsaneevithayakul2Sutin Sriussadaporn3Sathit Vannasaeng4Apiradee Sriwijitkamol5Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Corresponding author at: Department of Medicine, Faculty of Medicine Siriraj Hospital, 2 Wanglang Road, Siriraj, Bangkoknoi, Bangkok 10700, Thailand.Aim: To determine the prevalence of and risk factors for abnormal glucose tolerance (AGT) in previous gestational diabetes mellitus (pGDM) women. Methods: 100 pGDM women randomly selected from the database of the Department of Obstetrics/Gynecology. 75 g-OGTT were performed in subjects without known diabetes. AGT was diagnosed using the American Diabetes Association criteria. Results: The mean age, pre-gestational BMI, and time since delivery were 38 ± 5 years, 24.5 ± 5.7 kg/m2, and 46 ± 26 months. Overall, 81% of the subjects had AGT, including IGT (38%), IGT + IFG (5%), T2DM (38%). Plasma glucose (PG) at 1 h after a 50 g-glucose challenge test (GCT), PG at 1 h after 100 g-OGTT, HbA1c, and HOMA-IR were significantly greater in women with AGT than normal glucose tolerance (NGT) women. The proportion of women with ≥3 abnormal PG values during 100 g-OGTT was greater in AGT than NGT group (50.7% vs. 15.8%). Multivariate analysis showed that PG ≥ 150 mg/dl at 1 h after a 50 g-GCT and ≥3 abnormal PG values in 100 g-OGTTs were risk factors for developing AGT. Conclusions: Eighty-one percent of pGDM women developed AGT within 4 years after delivery. Risk factors for AGT were PG ≥ 150 mg/dl at 1 h after a 50 g-GCT and ≥3 abnormal PG values in a 100 g-OGTT. Keywords: Abnormal glucose tolerance, Postpartum diabetes, Gestational diabeteshttp://www.sciencedirect.com/science/article/pii/S2214623717300339 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sirisawat Wanthong Raweewan Lertwattanarak Prasert Sunsaneevithayakul Sutin Sriussadaporn Sathit Vannasaeng Apiradee Sriwijitkamol |
spellingShingle |
Sirisawat Wanthong Raweewan Lertwattanarak Prasert Sunsaneevithayakul Sutin Sriussadaporn Sathit Vannasaeng Apiradee Sriwijitkamol High prevalence of diabetes and abnormal glucose tolerance in Thai women with previous gestational diabetes mellitus Journal of Clinical & Translational Endocrinology |
author_facet |
Sirisawat Wanthong Raweewan Lertwattanarak Prasert Sunsaneevithayakul Sutin Sriussadaporn Sathit Vannasaeng Apiradee Sriwijitkamol |
author_sort |
Sirisawat Wanthong |
title |
High prevalence of diabetes and abnormal glucose tolerance in Thai women with previous gestational diabetes mellitus |
title_short |
High prevalence of diabetes and abnormal glucose tolerance in Thai women with previous gestational diabetes mellitus |
title_full |
High prevalence of diabetes and abnormal glucose tolerance in Thai women with previous gestational diabetes mellitus |
title_fullStr |
High prevalence of diabetes and abnormal glucose tolerance in Thai women with previous gestational diabetes mellitus |
title_full_unstemmed |
High prevalence of diabetes and abnormal glucose tolerance in Thai women with previous gestational diabetes mellitus |
title_sort |
high prevalence of diabetes and abnormal glucose tolerance in thai women with previous gestational diabetes mellitus |
publisher |
Elsevier |
series |
Journal of Clinical & Translational Endocrinology |
issn |
2214-6237 |
publishDate |
2017-09-01 |
description |
Aim: To determine the prevalence of and risk factors for abnormal glucose tolerance (AGT) in previous gestational diabetes mellitus (pGDM) women. Methods: 100 pGDM women randomly selected from the database of the Department of Obstetrics/Gynecology. 75 g-OGTT were performed in subjects without known diabetes. AGT was diagnosed using the American Diabetes Association criteria. Results: The mean age, pre-gestational BMI, and time since delivery were 38 ± 5 years, 24.5 ± 5.7 kg/m2, and 46 ± 26 months. Overall, 81% of the subjects had AGT, including IGT (38%), IGT + IFG (5%), T2DM (38%). Plasma glucose (PG) at 1 h after a 50 g-glucose challenge test (GCT), PG at 1 h after 100 g-OGTT, HbA1c, and HOMA-IR were significantly greater in women with AGT than normal glucose tolerance (NGT) women. The proportion of women with ≥3 abnormal PG values during 100 g-OGTT was greater in AGT than NGT group (50.7% vs. 15.8%). Multivariate analysis showed that PG ≥ 150 mg/dl at 1 h after a 50 g-GCT and ≥3 abnormal PG values in 100 g-OGTTs were risk factors for developing AGT. Conclusions: Eighty-one percent of pGDM women developed AGT within 4 years after delivery. Risk factors for AGT were PG ≥ 150 mg/dl at 1 h after a 50 g-GCT and ≥3 abnormal PG values in a 100 g-OGTT. Keywords: Abnormal glucose tolerance, Postpartum diabetes, Gestational diabetes |
url |
http://www.sciencedirect.com/science/article/pii/S2214623717300339 |
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