Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

DYRK1A, dual-specificity tyrosine-regulated kinase 1A, maps to human chromosome 21 within the Down syndrome (DS) critical region. Dyrk1 phosphorylates the human microtubule-associated protein tau at Thr212 in vitro, a residue that is phosphorylated in fetal tau and hyper-phosphorylated in Alzheimer...

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Bibliographic Details
Main Authors: Isidro Ferrer, Marta Barrachina, Berta Puig, M. Martínez de Lagrán, Eulalia Martí, Jesús Avila, Mara Dierssen
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neurobiology of Disease
Subjects:
tau
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000835

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