Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study.
The aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients (SOTRs) with COVID-19. We conducted a prospective observational cohort study of 210 consecutive SOTRs hospitalized with COVID-19 in 12 Spanish centers from 21 February to 6 May 2020...
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doaj-77775ee056aa47948eaabae4eac2b5e82021-05-15T04:30:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01164e025079610.1371/journal.pone.0250796Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study.Sonsoles Salto-AlejandreSilvia Jiménez-JorgeNuria SabéAntonio Ramos-MartínezLaura LinaresMaricela ValerioPilar Martín-DávilaMario Fernández-RuizMaría Carmen FariñasMarino Blanes-JuliáElisa VidalZaira R Palacios-BaenaRomán Hernández-GallegoJordi CarrataláJorge Calderón-ParraMaría Ángeles MarcosPatricia MuñozJesús Fortún-AbeteJosé María AguadoFrancisco Arnaiz-RevillasRosa Blanes-HernándezJulián de la Torre-CisnerosLuis E López-CortésElena García de Vinuesa-CalvoClara M RossoJerónimo PachónJavier Sánchez-CéspedesElisa CorderoCOVIDSOT Working TeamThe aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients (SOTRs) with COVID-19. We conducted a prospective observational cohort study of 210 consecutive SOTRs hospitalized with COVID-19 in 12 Spanish centers from 21 February to 6 May 2020. Data pertaining to demographics, chronic underlying diseases, transplantation features, clinical, therapeutics, and complications were collected. The primary endpoint was a composite of intensive care unit (ICU) admission and/or death. Logistic regression analyses were performed to identify the factors associated with these unfavorable outcomes. Males accounted for 148 (70.5%) patients, the median age was 63 years, and 189 (90.0%) patients had pneumonia. Common symptoms were fever, cough, gastrointestinal disturbances, and dyspnea. The most used antiviral or host-targeted therapies included hydroxychloroquine 193/200 (96.5%), lopinavir/ritonavir 91/200 (45.5%), and tocilizumab 49/200 (24.5%). Thirty-seven (17.6%) patients required ICU admission, 12 (5.7%) suffered graft dysfunction, and 45 (21.4%) died. A shorter interval between transplantation and COVID-19 diagnosis had a negative impact on clinical prognosis. Four baseline features were identified as independent predictors of intensive care need or death: advanced age, high respiratory rate, lymphopenia, and elevated level of lactate dehydrogenase. In summary, this study presents comprehensive information on characteristics and complications of COVID-19 in hospitalized SOTRs and provides indicators available upon hospital admission for the identification of SOTRs at risk of critical disease or death, underlining the need for stringent preventative measures in the early post-transplant period.https://doi.org/10.1371/journal.pone.0250796 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sonsoles Salto-Alejandre Silvia Jiménez-Jorge Nuria Sabé Antonio Ramos-Martínez Laura Linares Maricela Valerio Pilar Martín-Dávila Mario Fernández-Ruiz María Carmen Fariñas Marino Blanes-Juliá Elisa Vidal Zaira R Palacios-Baena Román Hernández-Gallego Jordi Carratalá Jorge Calderón-Parra María Ángeles Marcos Patricia Muñoz Jesús Fortún-Abete José María Aguado Francisco Arnaiz-Revillas Rosa Blanes-Hernández Julián de la Torre-Cisneros Luis E López-Cortés Elena García de Vinuesa-Calvo Clara M Rosso Jerónimo Pachón Javier Sánchez-Céspedes Elisa Cordero COVIDSOT Working Team |
spellingShingle |
Sonsoles Salto-Alejandre Silvia Jiménez-Jorge Nuria Sabé Antonio Ramos-Martínez Laura Linares Maricela Valerio Pilar Martín-Dávila Mario Fernández-Ruiz María Carmen Fariñas Marino Blanes-Juliá Elisa Vidal Zaira R Palacios-Baena Román Hernández-Gallego Jordi Carratalá Jorge Calderón-Parra María Ángeles Marcos Patricia Muñoz Jesús Fortún-Abete José María Aguado Francisco Arnaiz-Revillas Rosa Blanes-Hernández Julián de la Torre-Cisneros Luis E López-Cortés Elena García de Vinuesa-Calvo Clara M Rosso Jerónimo Pachón Javier Sánchez-Céspedes Elisa Cordero COVIDSOT Working Team Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study. PLoS ONE |
author_facet |
Sonsoles Salto-Alejandre Silvia Jiménez-Jorge Nuria Sabé Antonio Ramos-Martínez Laura Linares Maricela Valerio Pilar Martín-Dávila Mario Fernández-Ruiz María Carmen Fariñas Marino Blanes-Juliá Elisa Vidal Zaira R Palacios-Baena Román Hernández-Gallego Jordi Carratalá Jorge Calderón-Parra María Ángeles Marcos Patricia Muñoz Jesús Fortún-Abete José María Aguado Francisco Arnaiz-Revillas Rosa Blanes-Hernández Julián de la Torre-Cisneros Luis E López-Cortés Elena García de Vinuesa-Calvo Clara M Rosso Jerónimo Pachón Javier Sánchez-Céspedes Elisa Cordero COVIDSOT Working Team |
author_sort |
Sonsoles Salto-Alejandre |
title |
Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study. |
title_short |
Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study. |
title_full |
Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study. |
title_fullStr |
Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study. |
title_full_unstemmed |
Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study. |
title_sort |
risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with covid-19: a prospective multicenter cohort study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2021-01-01 |
description |
The aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients (SOTRs) with COVID-19. We conducted a prospective observational cohort study of 210 consecutive SOTRs hospitalized with COVID-19 in 12 Spanish centers from 21 February to 6 May 2020. Data pertaining to demographics, chronic underlying diseases, transplantation features, clinical, therapeutics, and complications were collected. The primary endpoint was a composite of intensive care unit (ICU) admission and/or death. Logistic regression analyses were performed to identify the factors associated with these unfavorable outcomes. Males accounted for 148 (70.5%) patients, the median age was 63 years, and 189 (90.0%) patients had pneumonia. Common symptoms were fever, cough, gastrointestinal disturbances, and dyspnea. The most used antiviral or host-targeted therapies included hydroxychloroquine 193/200 (96.5%), lopinavir/ritonavir 91/200 (45.5%), and tocilizumab 49/200 (24.5%). Thirty-seven (17.6%) patients required ICU admission, 12 (5.7%) suffered graft dysfunction, and 45 (21.4%) died. A shorter interval between transplantation and COVID-19 diagnosis had a negative impact on clinical prognosis. Four baseline features were identified as independent predictors of intensive care need or death: advanced age, high respiratory rate, lymphopenia, and elevated level of lactate dehydrogenase. In summary, this study presents comprehensive information on characteristics and complications of COVID-19 in hospitalized SOTRs and provides indicators available upon hospital admission for the identification of SOTRs at risk of critical disease or death, underlining the need for stringent preventative measures in the early post-transplant period. |
url |
https://doi.org/10.1371/journal.pone.0250796 |
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