Metastatic oral malignant melanoma transformed from pre-existing pigmented lesions in mandibular gingiva: Report of an unusual case
The objective of this study is to report the transformation of a 10-year history of melanotic mandibular gingival lesion into primary oral melanoma (POM) in a 37-year-old Taiwanese woman. The patient declined all treatments and died of widespread disease 15 months after POM was confirmed. The histol...
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doaj-778febe7b7ab49a3881ff50794f101c42020-11-24T22:37:41ZengElsevierJournal of Dental Sciences1991-79022013-09-018332833210.1016/j.jds.2012.11.005Metastatic oral malignant melanoma transformed from pre-existing pigmented lesions in mandibular gingiva: Report of an unusual caseShin-Yu Lu0Chin-Fan Lin1Shun-Chen Huang2Oral Pathology and Family Dentistry Section, Department of Dentistry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, TaiwanOral Pathology and Family Dentistry Section, Department of Dentistry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, TaiwanDepartment of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, TaiwanThe objective of this study is to report the transformation of a 10-year history of melanotic mandibular gingival lesion into primary oral melanoma (POM) in a 37-year-old Taiwanese woman. The patient declined all treatments and died of widespread disease 15 months after POM was confirmed. The histology of initial biopsies was totally benign, but the size of lesion, irregular shape, and developing satellites of pigmentation at the periphery were clinically atypical. However atypical it was, this clinical appearance was unknown to the pathologists. This case demonstrates that oral melanoma can be preceded by a histologically benign-appearing flat pigmented lesion for an extended time. Therefore, a benign oral pigmentation should not be viewed as a harmless condition and regular periodical follow-up is necessary. We argue that the diagnosis and risk assessment of oral pigmented lesions require a team effort from both clinicians and pathologists to make an appropriate diagnosis and achieve a favorable prognosis.http://www.sciencedirect.com/science/article/pii/S1991790213000135hyperpigmentationmelanosismelanotic maculeoral melanoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shin-Yu Lu Chin-Fan Lin Shun-Chen Huang |
spellingShingle |
Shin-Yu Lu Chin-Fan Lin Shun-Chen Huang Metastatic oral malignant melanoma transformed from pre-existing pigmented lesions in mandibular gingiva: Report of an unusual case Journal of Dental Sciences hyperpigmentation melanosis melanotic macule oral melanoma |
author_facet |
Shin-Yu Lu Chin-Fan Lin Shun-Chen Huang |
author_sort |
Shin-Yu Lu |
title |
Metastatic oral malignant melanoma transformed from pre-existing pigmented lesions in mandibular gingiva: Report of an unusual case |
title_short |
Metastatic oral malignant melanoma transformed from pre-existing pigmented lesions in mandibular gingiva: Report of an unusual case |
title_full |
Metastatic oral malignant melanoma transformed from pre-existing pigmented lesions in mandibular gingiva: Report of an unusual case |
title_fullStr |
Metastatic oral malignant melanoma transformed from pre-existing pigmented lesions in mandibular gingiva: Report of an unusual case |
title_full_unstemmed |
Metastatic oral malignant melanoma transformed from pre-existing pigmented lesions in mandibular gingiva: Report of an unusual case |
title_sort |
metastatic oral malignant melanoma transformed from pre-existing pigmented lesions in mandibular gingiva: report of an unusual case |
publisher |
Elsevier |
series |
Journal of Dental Sciences |
issn |
1991-7902 |
publishDate |
2013-09-01 |
description |
The objective of this study is to report the transformation of a 10-year history of melanotic mandibular gingival lesion into primary oral melanoma (POM) in a 37-year-old Taiwanese woman. The patient declined all treatments and died of widespread disease 15 months after POM was confirmed. The histology of initial biopsies was totally benign, but the size of lesion, irregular shape, and developing satellites of pigmentation at the periphery were clinically atypical. However atypical it was, this clinical appearance was unknown to the pathologists. This case demonstrates that oral melanoma can be preceded by a histologically benign-appearing flat pigmented lesion for an extended time. Therefore, a benign oral pigmentation should not be viewed as a harmless condition and regular periodical follow-up is necessary. We argue that the diagnosis and risk assessment of oral pigmented lesions require a team effort from both clinicians and pathologists to make an appropriate diagnosis and achieve a favorable prognosis. |
topic |
hyperpigmentation melanosis melanotic macule oral melanoma |
url |
http://www.sciencedirect.com/science/article/pii/S1991790213000135 |
work_keys_str_mv |
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