VEGF (Vascular Endothelial Growth Factor) and Fibrotic Lung Disease
Interstitial lung disease (ILD) encompasses a group of heterogeneous diseases characterised by varying degrees of aberrant inflammation and fibrosis of the lung parenchyma. This may occur in isolation, such as in idiopathic pulmonary fibrosis (IPF) or as part of a wider disease process affecting mul...
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doaj-77905db4da2b46b1b18b5cf3462a83572020-11-24T21:46:32ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-04-01195126910.3390/ijms19051269ijms19051269VEGF (Vascular Endothelial Growth Factor) and Fibrotic Lung DiseaseShaney L. Barratt0Victoria A. Flower1John D. Pauling2Ann B. Millar3Academic Respiratory Unit, School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, UKDepartment of Pharmacy and Pharmacology, University of Bath, Bath BA1 1RL, UKDepartment of Pharmacy and Pharmacology, University of Bath, Bath BA1 1RL, UKAcademic Respiratory Unit, School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, UKInterstitial lung disease (ILD) encompasses a group of heterogeneous diseases characterised by varying degrees of aberrant inflammation and fibrosis of the lung parenchyma. This may occur in isolation, such as in idiopathic pulmonary fibrosis (IPF) or as part of a wider disease process affecting multiple organs, such as in systemic sclerosis. Anti-Vascular Endothelial Growth Factor (anti-VEGF) therapy is one component of an existing broad-spectrum therapeutic option in IPF (nintedanib) and may become part of the emerging therapeutic strategy for other ILDs in the future. This article describes our current understanding of VEGF biology in normal lung homeostasis and how changes in its bioavailability may contribute the pathogenesis of ILD. The complexity of VEGF biology is particularly highlighted with an emphasis on the potential non-vascular, non-angiogenic roles for VEGF in the lung, in both health and disease.http://www.mdpi.com/1422-0067/19/5/1269interstitial lung diseasefibrosisVascular Endothelial Growth FactorVEGF |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shaney L. Barratt Victoria A. Flower John D. Pauling Ann B. Millar |
spellingShingle |
Shaney L. Barratt Victoria A. Flower John D. Pauling Ann B. Millar VEGF (Vascular Endothelial Growth Factor) and Fibrotic Lung Disease International Journal of Molecular Sciences interstitial lung disease fibrosis Vascular Endothelial Growth Factor VEGF |
author_facet |
Shaney L. Barratt Victoria A. Flower John D. Pauling Ann B. Millar |
author_sort |
Shaney L. Barratt |
title |
VEGF (Vascular Endothelial Growth Factor) and Fibrotic Lung Disease |
title_short |
VEGF (Vascular Endothelial Growth Factor) and Fibrotic Lung Disease |
title_full |
VEGF (Vascular Endothelial Growth Factor) and Fibrotic Lung Disease |
title_fullStr |
VEGF (Vascular Endothelial Growth Factor) and Fibrotic Lung Disease |
title_full_unstemmed |
VEGF (Vascular Endothelial Growth Factor) and Fibrotic Lung Disease |
title_sort |
vegf (vascular endothelial growth factor) and fibrotic lung disease |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-04-01 |
description |
Interstitial lung disease (ILD) encompasses a group of heterogeneous diseases characterised by varying degrees of aberrant inflammation and fibrosis of the lung parenchyma. This may occur in isolation, such as in idiopathic pulmonary fibrosis (IPF) or as part of a wider disease process affecting multiple organs, such as in systemic sclerosis. Anti-Vascular Endothelial Growth Factor (anti-VEGF) therapy is one component of an existing broad-spectrum therapeutic option in IPF (nintedanib) and may become part of the emerging therapeutic strategy for other ILDs in the future. This article describes our current understanding of VEGF biology in normal lung homeostasis and how changes in its bioavailability may contribute the pathogenesis of ILD. The complexity of VEGF biology is particularly highlighted with an emphasis on the potential non-vascular, non-angiogenic roles for VEGF in the lung, in both health and disease. |
topic |
interstitial lung disease fibrosis Vascular Endothelial Growth Factor VEGF |
url |
http://www.mdpi.com/1422-0067/19/5/1269 |
work_keys_str_mv |
AT shaneylbarratt vegfvascularendothelialgrowthfactorandfibroticlungdisease AT victoriaaflower vegfvascularendothelialgrowthfactorandfibroticlungdisease AT johndpauling vegfvascularendothelialgrowthfactorandfibroticlungdisease AT annbmillar vegfvascularendothelialgrowthfactorandfibroticlungdisease |
_version_ |
1725901527056384000 |