Cancer predictive studies
Abstract The identification of individual or clusters of predictive genetic alterations might help in defining the outcome of cancer treatment, allowing for the stratification of patients into distinct cohorts for selective therapeutic protocols. Neuroblastoma (NB) is the most common extracranial ch...
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Format: | Article |
Language: | English |
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BMC
2020-10-01
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Series: | Biology Direct |
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Online Access: | http://link.springer.com/article/10.1186/s13062-020-00274-3 |
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doaj-779490d6140247d6a970fa89d34e81df |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ivano Amelio Riccardo Bertolo Pierluigi Bove Eleonora Candi Marcello Chiocchi Chiara Cipriani Nicola Di Daniele Carlo Ganini Hartmut Juhl Alessandro Mauriello Carla Marani John Marshall Manuela Montanaro Giampiero Palmieri Mauro Piacentini Giuseppe Sica Manfredi Tesauro Valentina Rovella Giuseppe Tisone Yufang Shi Ying Wang Gerry Melino |
spellingShingle |
Ivano Amelio Riccardo Bertolo Pierluigi Bove Eleonora Candi Marcello Chiocchi Chiara Cipriani Nicola Di Daniele Carlo Ganini Hartmut Juhl Alessandro Mauriello Carla Marani John Marshall Manuela Montanaro Giampiero Palmieri Mauro Piacentini Giuseppe Sica Manfredi Tesauro Valentina Rovella Giuseppe Tisone Yufang Shi Ying Wang Gerry Melino Cancer predictive studies Biology Direct Neuroblastoma Microbiota Precision oncology Omics |
author_facet |
Ivano Amelio Riccardo Bertolo Pierluigi Bove Eleonora Candi Marcello Chiocchi Chiara Cipriani Nicola Di Daniele Carlo Ganini Hartmut Juhl Alessandro Mauriello Carla Marani John Marshall Manuela Montanaro Giampiero Palmieri Mauro Piacentini Giuseppe Sica Manfredi Tesauro Valentina Rovella Giuseppe Tisone Yufang Shi Ying Wang Gerry Melino |
author_sort |
Ivano Amelio |
title |
Cancer predictive studies |
title_short |
Cancer predictive studies |
title_full |
Cancer predictive studies |
title_fullStr |
Cancer predictive studies |
title_full_unstemmed |
Cancer predictive studies |
title_sort |
cancer predictive studies |
publisher |
BMC |
series |
Biology Direct |
issn |
1745-6150 |
publishDate |
2020-10-01 |
description |
Abstract The identification of individual or clusters of predictive genetic alterations might help in defining the outcome of cancer treatment, allowing for the stratification of patients into distinct cohorts for selective therapeutic protocols. Neuroblastoma (NB) is the most common extracranial childhood tumour, clinically defined in five distinct stages (1–4 & 4S), where stages 3–4 define chemotherapy-resistant, highly aggressive disease phases. NB is a model for geneticists and molecular biologists to classify genetic abnormalities and identify causative disease genes. Despite highly intensive basic research, improvements on clinical outcome have been predominantly observed for less aggressive cancers, that is stages 1,2 and 4S. Therefore, stages 3–4 NB are still complicated at the therapeutic level and require more intense fundamental research. Using neuroblastoma as a model system, here we herein outline how cancer prediction studies can help at steering preclinical and clinical research toward the identification and exploitation of specific genetic landscape. This might result in maximising the therapeutic success and minimizing harmful effects in cancer patients. |
topic |
Neuroblastoma Microbiota Precision oncology Omics |
url |
http://link.springer.com/article/10.1186/s13062-020-00274-3 |
work_keys_str_mv |
AT ivanoamelio cancerpredictivestudies AT riccardobertolo cancerpredictivestudies AT pierluigibove cancerpredictivestudies AT eleonoracandi cancerpredictivestudies AT marcellochiocchi cancerpredictivestudies AT chiaracipriani cancerpredictivestudies AT nicoladidaniele cancerpredictivestudies AT carloganini cancerpredictivestudies AT hartmutjuhl cancerpredictivestudies AT alessandromauriello cancerpredictivestudies AT carlamarani cancerpredictivestudies AT johnmarshall cancerpredictivestudies AT manuelamontanaro cancerpredictivestudies AT giampieropalmieri cancerpredictivestudies AT mauropiacentini cancerpredictivestudies AT giuseppesica cancerpredictivestudies AT manfreditesauro cancerpredictivestudies AT valentinarovella cancerpredictivestudies AT giuseppetisone cancerpredictivestudies AT yufangshi cancerpredictivestudies AT yingwang cancerpredictivestudies AT gerrymelino cancerpredictivestudies |
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1724448156862644224 |
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doaj-779490d6140247d6a970fa89d34e81df2020-11-25T04:00:59ZengBMCBiology Direct1745-61502020-10-011511710.1186/s13062-020-00274-3Cancer predictive studiesIvano Amelio0Riccardo Bertolo1Pierluigi Bove2Eleonora Candi3Marcello Chiocchi4Chiara Cipriani5Nicola Di Daniele6Carlo Ganini7Hartmut Juhl8Alessandro Mauriello9Carla Marani10John Marshall11Manuela Montanaro12Giampiero Palmieri13Mauro Piacentini14Giuseppe Sica15Manfredi Tesauro16Valentina Rovella17Giuseppe Tisone18Yufang Shi19Ying Wang20Gerry Melino21Torvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataIndivumed GmbHTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataMedstar Georgetown University Hospital, Georgetown UniversityTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of SciencesTorvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor VergataAbstract The identification of individual or clusters of predictive genetic alterations might help in defining the outcome of cancer treatment, allowing for the stratification of patients into distinct cohorts for selective therapeutic protocols. Neuroblastoma (NB) is the most common extracranial childhood tumour, clinically defined in five distinct stages (1–4 & 4S), where stages 3–4 define chemotherapy-resistant, highly aggressive disease phases. NB is a model for geneticists and molecular biologists to classify genetic abnormalities and identify causative disease genes. Despite highly intensive basic research, improvements on clinical outcome have been predominantly observed for less aggressive cancers, that is stages 1,2 and 4S. Therefore, stages 3–4 NB are still complicated at the therapeutic level and require more intense fundamental research. Using neuroblastoma as a model system, here we herein outline how cancer prediction studies can help at steering preclinical and clinical research toward the identification and exploitation of specific genetic landscape. This might result in maximising the therapeutic success and minimizing harmful effects in cancer patients.http://link.springer.com/article/10.1186/s13062-020-00274-3NeuroblastomaMicrobiotaPrecision oncologyOmics |