Sonidegib: Safety and Efficacy in Treatment of Advanced Basal Cell Carcinoma
Abstract Hedgehog inhibitors are promising alternative treatments for patients with advanced basal cell carcinomas. Sonidegib (Odomzo®), an oral smoothened (SMO) antagonist, is indicated for the treatment of adult patients with locally advanced basal cell carcinoma (laBCC) who present recurrence fol...
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doaj-779dc109b6964e7386f5a8d14aca43732021-04-18T11:16:17ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722020-04-0110340141210.1007/s13555-020-00378-8Sonidegib: Safety and Efficacy in Treatment of Advanced Basal Cell CarcinomaAlessia Villani0Gabriella Fabbrocini1Claudia Costa2Massimiliano Scalvenzi3Dermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico IIDermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico IIDermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico IIDermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico IIAbstract Hedgehog inhibitors are promising alternative treatments for patients with advanced basal cell carcinomas. Sonidegib (Odomzo®), an oral smoothened (SMO) antagonist, is indicated for the treatment of adult patients with locally advanced basal cell carcinoma (laBCC) who present recurrence following surgery or radiation therapy, or those who are not candidates for surgery or radiotherapy. Several studies and randomized controlled trials have been conducted to evaluate the efficacy, safety, and tolerability of this new molecule that has demonstrated a good response rate (44%). Grade 1–2 adverse events have also been reported. Further studies of real-world experiences are needed to better understand the correct management of the drug, alternative dosing regimens, and differences with other hedgehog inhibitors. This article provides a complete overview of the pharmacology and pharmacokinetics of sonidegib and a report of the trials and studies conducted. The most frequent adverse events and their correct management are also discussed.https://doi.org/10.1007/s13555-020-00378-8Adverse eventsBasal cell carcinomaHedgehog inhibitorsSonidegib |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alessia Villani Gabriella Fabbrocini Claudia Costa Massimiliano Scalvenzi |
spellingShingle |
Alessia Villani Gabriella Fabbrocini Claudia Costa Massimiliano Scalvenzi Sonidegib: Safety and Efficacy in Treatment of Advanced Basal Cell Carcinoma Dermatology and Therapy Adverse events Basal cell carcinoma Hedgehog inhibitors Sonidegib |
author_facet |
Alessia Villani Gabriella Fabbrocini Claudia Costa Massimiliano Scalvenzi |
author_sort |
Alessia Villani |
title |
Sonidegib: Safety and Efficacy in Treatment of Advanced Basal Cell Carcinoma |
title_short |
Sonidegib: Safety and Efficacy in Treatment of Advanced Basal Cell Carcinoma |
title_full |
Sonidegib: Safety and Efficacy in Treatment of Advanced Basal Cell Carcinoma |
title_fullStr |
Sonidegib: Safety and Efficacy in Treatment of Advanced Basal Cell Carcinoma |
title_full_unstemmed |
Sonidegib: Safety and Efficacy in Treatment of Advanced Basal Cell Carcinoma |
title_sort |
sonidegib: safety and efficacy in treatment of advanced basal cell carcinoma |
publisher |
Adis, Springer Healthcare |
series |
Dermatology and Therapy |
issn |
2193-8210 2190-9172 |
publishDate |
2020-04-01 |
description |
Abstract Hedgehog inhibitors are promising alternative treatments for patients with advanced basal cell carcinomas. Sonidegib (Odomzo®), an oral smoothened (SMO) antagonist, is indicated for the treatment of adult patients with locally advanced basal cell carcinoma (laBCC) who present recurrence following surgery or radiation therapy, or those who are not candidates for surgery or radiotherapy. Several studies and randomized controlled trials have been conducted to evaluate the efficacy, safety, and tolerability of this new molecule that has demonstrated a good response rate (44%). Grade 1–2 adverse events have also been reported. Further studies of real-world experiences are needed to better understand the correct management of the drug, alternative dosing regimens, and differences with other hedgehog inhibitors. This article provides a complete overview of the pharmacology and pharmacokinetics of sonidegib and a report of the trials and studies conducted. The most frequent adverse events and their correct management are also discussed. |
topic |
Adverse events Basal cell carcinoma Hedgehog inhibitors Sonidegib |
url |
https://doi.org/10.1007/s13555-020-00378-8 |
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1721522513559683072 |