Four Different Markers for Activated Cell Mediated Immunity Compared with the Clinical Stages of HIV Infection

Four Different Markers for Activated Cell Mediated Immunity Compared with the Clinical Stages of HIV Infection

Activated cell-mediated immunity, as defined by four markers, has been studied in HIV-infected patients, and compared with the clinical stages of HIV infection. All the values obtained with such markers (interferon-y expressed on lymphocytes, soluble CD8, soluble IL-2 receptor, and serum neopterin)...

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Main Authors: Caruso Arnaldo, Francesco Maria de, Gonzales Rosanna, Pollara Patrizia, Zanoni Lorenzo, Foresti Ida, Turano Adolfo
Format: Article
Language:English
Published: De Gruyter 1990-01-01
Series:Pteridines
Online Access:https://doi.org/10.1515/pteridines.1990.2.1.51
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spelling doaj-779e7e4510794adeb3b2cf40892dbfe52021-09-05T13:59:58ZengDe GruyterPteridines0933-48072195-47201990-01-0121515710.1515/pteridines.1990.2.1.51Four Different Markers for Activated Cell Mediated Immunity Compared with the Clinical Stages of HIV InfectionCaruso Arnaldo0Francesco Maria de1Gonzales Rosanna2Pollara Patrizia3Zanoni Lorenzo4Foresti Ida5Turano Adolfo6Institute of Microbiology, University of Brescia, Piazza Spedali Civili, 1, 1-25123 Brescia, ItalyInstitute of Microbiology, University of Brescia, Piazza Spedali Civili, 1, 1-25123 Brescia, ItalyInstitute of Microbiology, University of Brescia, Piazza Spedali Civili, 1, 1-25123 Brescia, ItalyInstitute of Microbiology, University of Brescia, Piazza Spedali Civili, 1, 1-25123 Brescia, ItalyInstitute of Microbiology, University of Brescia, Piazza Spedali Civili, 1, 1-25123 Brescia, ItalyInstitute of Microbiology, University of Brescia, Piazza Spedali Civili, 1, 1-25123 Brescia, ItalyInstitute of Microbiology, University of Brescia, Piazza Spedali Civili, 1, 1-25123 Brescia, ItalyActivated cell-mediated immunity, as defined by four markers, has been studied in HIV-infected patients, and compared with the clinical stages of HIV infection. All the values obtained with such markers (interferon-y expressed on lymphocytes, soluble CD8, soluble IL-2 receptor, and serum neopterin) were observed to increase with the progressive stages of HIV infection, with the highest figures occurring in stage IV-C patients. Since the replication of HIV depend strictly on the stimulation of infected cells, T-cell activation in vitro might contribute to a further spread of HIV-1 in infected subjects. Thus permanent or multiple stimulation of the cellular immune system could be an important cofactor in the progression of this syndrome.https://doi.org/10.1515/pteridines.1990.2.1.51
collection DOAJ
language English
format Article
sources DOAJ
author Caruso Arnaldo
Francesco Maria de
Gonzales Rosanna
Pollara Patrizia
Zanoni Lorenzo
Foresti Ida
Turano Adolfo
spellingShingle Caruso Arnaldo
Francesco Maria de
Gonzales Rosanna
Pollara Patrizia
Zanoni Lorenzo
Foresti Ida
Turano Adolfo
Four Different Markers for Activated Cell Mediated Immunity Compared with the Clinical Stages of HIV Infection
Pteridines
author_facet Caruso Arnaldo
Francesco Maria de
Gonzales Rosanna
Pollara Patrizia
Zanoni Lorenzo
Foresti Ida
Turano Adolfo
author_sort Caruso Arnaldo
title Four Different Markers for Activated Cell Mediated Immunity Compared with the Clinical Stages of HIV Infection
title_short Four Different Markers for Activated Cell Mediated Immunity Compared with the Clinical Stages of HIV Infection
title_full Four Different Markers for Activated Cell Mediated Immunity Compared with the Clinical Stages of HIV Infection
title_fullStr Four Different Markers for Activated Cell Mediated Immunity Compared with the Clinical Stages of HIV Infection
title_full_unstemmed Four Different Markers for Activated Cell Mediated Immunity Compared with the Clinical Stages of HIV Infection
title_sort four different markers for activated cell mediated immunity compared with the clinical stages of hiv infection
publisher De Gruyter
series Pteridines
issn 0933-4807
2195-4720
publishDate 1990-01-01
description Activated cell-mediated immunity, as defined by four markers, has been studied in HIV-infected patients, and compared with the clinical stages of HIV infection. All the values obtained with such markers (interferon-y expressed on lymphocytes, soluble CD8, soluble IL-2 receptor, and serum neopterin) were observed to increase with the progressive stages of HIV infection, with the highest figures occurring in stage IV-C patients. Since the replication of HIV depend strictly on the stimulation of infected cells, T-cell activation in vitro might contribute to a further spread of HIV-1 in infected subjects. Thus permanent or multiple stimulation of the cellular immune system could be an important cofactor in the progression of this syndrome.
url https://doi.org/10.1515/pteridines.1990.2.1.51
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