Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

Wnt/β-catenin activation in adult epidermis can induce new hair follicle formation and tumor development. We used lineage tracing to uncover the relative contribution of different stem cell populations. LGR6+ and LRIG1+ stem cells contributed to ectopic hair follicles formed in the sebaceous gland u...

Full description

Bibliographic Details
Main Authors:	Kai Kretzschmar, Christine Weber, Ryan R. Driskell, Eduardo Calonje, Fiona M. Watt
Format:	Article
Language:	English
Published:	Elsevier 2016-01-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124715014825

Similar Items

Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages
by: Beate M. Lichtenberger, et al.
Published: (2016-02-01)

Remodelling adult mouse skin by epidermal β-catenin activation
by: Kretzschmar, Kai
Published: (2014)

Targeting CD147 for T to NK Lineage Reprogramming and Tumor Therapy
by: Jie-Jie Geng, et al.
Published: (2017-06-01)

Role of β-catenin signalling in adult epidermal cell fate specification
by: Celso, Cristina Lo
Published: (2005)

Successful Reprogramming of Epiblast Stem Cells by Blocking Nuclear Localization of β-Catenin
by: Hideyuki Murayama, et al.
Published: (2015-01-01)

Wnt/β-Catenin Signaling Triggers Neuron Reprogramming and Regeneration in the Mouse Retina
by: Daniela Sanges, et al.
Published: (2013-07-01)

Cellular Reprogramming toward the Erythroid Lineage
by: Laura J. Norton, et al.
Published: (2011-01-01)

β-Catenin Fluctuates in Mouse ESCs and Is Essential for Nanog-Mediated Reprogramming of Somatic Cells to Pluripotency
by: Lucia Marucci, et al.
Published: (2014-09-01)

Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells
by: Arsham Ghahramani, et al.
Published: (2018-01-01)

Lineage Reprogramming of Effector Regulatory T Cells in Cancer
by: Michael L. Dixon, et al.
Published: (2021-07-01)

Chromatin Dynamics in Lineage Commitment and Cellular Reprogramming
by: Virlana M. Shchuka, et al.
Published: (2015-07-01)

Transient Expression of WNT2 Promotes Somatic Cell Reprogramming by Inducing β-Catenin Nuclear Accumulation
by: Mizuki Kimura, et al.
Published: (2016-06-01)

β-catenin signalling and lineage commitment of mouse ES cells : a single cell analysis
by: Trott, Jamie Francis
Published: (2013)

Deletion of Mediator 1 suppresses TGFβ signaling leading to changes in epidermal lineages and regeneration.
by: Yuko Oda, et al.
Published: (2020-01-01)

Epidermal growth factor receptor regulates β-catenin location, stability, and transcriptional activity in oral cancer
by: Hung Hsing-Wen, et al.
Published: (2010-03-01)

Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt.
by: Frank A Suprynowicz, et al.
Published: (2017-01-01)

The Role of Wnt/β-catenin Signaling Pathway in Rat Primordial Germ Cells Reprogramming and Induction into Pluripotent State
by: Alireza Mohammadi, et al.
Published: (2014-06-01)

The role of insulin resistance in metabolic reprogramming and lineage commitment
by: Dário Lúcio Ferreira de Jesus
Published: (2019)

Glucocorticoids Influencing Wnt/β-Catenin Pathway; Multiple Sites, Heterogeneous Effects
by: Katalin Meszaros, et al.
Published: (2020-03-01)

Small-Molecule-Based Lineage Reprogramming Creates Functional Astrocytes
by: E Tian, et al.
Published: (2016-07-01)

Fusion of Reprogramming Factors Alters the Trajectory of Somatic Lineage Conversion
by: Sergiy Velychko, et al.
Published: (2019-04-01)

Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming
by: Stefan H. Stricker, et al.
Published: (2021-01-01)

Reprogramming of mouse fibroblasts into neural lineage cells using biomaterials
by: Fahsai Kantawong, et al.
Published: (2018-03-01)

Application Of Heterogeneous Computing Techniques To Compartmental Spatiotemporal Epidemic Models
by: Brown, Grant Donald
Published: (2015)

Compartmental Modelling of ICG Pharmacokimetrics for Breast Tumors
Published: ()

PDGF Facilitates Direct Lineage Reprogramming of Hepatocytes to Functional β-Like Cells Induced by Pdx1 and Ngn3
by: Fang-Pei Chang, et al.
Published: (2016-10-01)

Epidermal growth factor promotes intestinal secretory cell differentiation in weaning piglets via Wnt/β-catenin signalling
by: L.X. Wang, et al.
Published: (2020-01-01)

Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
by: Chung-Ming Lin, et al.
Published: (2017-03-01)

A Selective β−Catenin-Metadherin/CEACAM1-CCL3 Axis Mediates Metastatic Heterogeneity upon Tumor–Macrophage Interaction
by: Chan, K.K.L, et al.
Published: (2022)

Astragaloside IV Enhances Melanogenesis via the AhR-Dependent AKT/GSK-3β/β-Catenin Pathway in Normal Human Epidermal Melanocytes
by: Baoyi Liu, et al.
Published: (2020-01-01)

Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming
by: Ke Xu, et al.
Published: (2018-05-01)

Modeling Heterogeneity in Direct Infectious Disease Transmission in a Compartmental Model
by: Lingcai Kong, et al.
Published: (2016-02-01)

Epidermal YAP activity drives canonical WNT16/β-catenin signaling to promote keratinocyte proliferation in vitro and in the murine skin
by: Veronica Mendoza-Reinoso, et al.
Published: (2018-05-01)

Luteolin-7-glucoside Promotes Human Epidermal Stem Cell Proliferation by Upregulating β-Catenin, c-Myc, and Cyclin Expression
by: Dapeng Wan, et al.
Published: (2019-01-01)

Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling
by: Haihua Zhang, et al.
Published: (2016-06-01)

PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating β-CateninY654Summary
by: Chenxi Gao, et al.
Published: (2019-01-01)

Wnt/ß-catenin signaling pathway in non-myocyte lineages in the heart
by: Fang, Ming
Published: (2016)

KIF18B promotes tumor progression in osteosarcoma by activating β-catenin
by: Tian Gao, et al.
Published: (2020-05-01)

Inhibition of Wnt/β-Catenin Signaling in Neuroendocrine Tumors In Vitro: Antitumoral Effects
by: Xi-Feng Jin, et al.
Published: (2020-02-01)

β-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells
by: Wendan Yu, et al.
Published: (2017-11-01)