Channelopathies - Emerging Trends in The Management of Inherited Arrhythmias
In spite of their relative rarity, inheritable arrhythmias have come to the forefront as a group of potentially fatal but preventable cause of sudden cardiac death in children and (young) adults. Comprehensive management of inherited arrhythmias includes diagnosing and treating the proband and ident...
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doaj-77b1a46ef7f8442ebb5199e48275903f2020-11-25T00:09:43ZengElsevierIndian Pacing and Electrophysiology Journal0972-62922015-01-01151435410.1016/S0972-6292(16)30841-5Channelopathies - Emerging Trends in The Management of Inherited ArrhythmiasPriya Chockalingam, MBBS, MRCPCH, PhD0Yuka Mizusawa, MD1Arthur A.M. Wilde, MD, PhD2Cardiac Wellness Institute, Chennai, IndiaAcademic Medical Center, Amsterdam, The NetherlandsAcademic Medical Center, Amsterdam, The NetherlandsIn spite of their relative rarity, inheritable arrhythmias have come to the forefront as a group of potentially fatal but preventable cause of sudden cardiac death in children and (young) adults. Comprehensive management of inherited arrhythmias includes diagnosing and treating the proband and identifying and protecting affected family members. This has been made possible by the vast advances in the field of molecular biology enabling better understanding of the genetic underpinnings of some of these disease groups, namely congenital long QT syndrome, catecholaminergic polymorphic ventricular tachycardia and Brugada syndrome. The ensuing knowledge of the genotype-phenotype correlations enables us to risk-stratify, prognosticate and treat based on the genetic test results. The various diagnostic modalities currently available to us, including clinical tools and genetic technologies, have to be applied judiciously in order to promptly identify those affected and to spare the emotional burden of a potentially lethal disease in the unaffected individuals. The therapeutic armamentarium of inherited arrhythmias includes pharmacological agents, device therapies and surgical interventions. A treatment strategy keeping in mind the risk profile of the patients, the local availability of drugs and the expertise of the treating personnel is proving effective. While opportunities for research are numerous in this expanding field of medicine, there is also tremendous scope for incorporating the emerging trends in managing patients and families with inherited arrhythmias in the Indian subcontinent.http://www.sciencedirect.com/science/article/pii/S0972629216308415ChannelopathiesInherited Arrhythmias |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Priya Chockalingam, MBBS, MRCPCH, PhD Yuka Mizusawa, MD Arthur A.M. Wilde, MD, PhD |
spellingShingle |
Priya Chockalingam, MBBS, MRCPCH, PhD Yuka Mizusawa, MD Arthur A.M. Wilde, MD, PhD Channelopathies - Emerging Trends in The Management of Inherited Arrhythmias Indian Pacing and Electrophysiology Journal Channelopathies Inherited Arrhythmias |
author_facet |
Priya Chockalingam, MBBS, MRCPCH, PhD Yuka Mizusawa, MD Arthur A.M. Wilde, MD, PhD |
author_sort |
Priya Chockalingam, MBBS, MRCPCH, PhD |
title |
Channelopathies - Emerging Trends in The Management of Inherited Arrhythmias |
title_short |
Channelopathies - Emerging Trends in The Management of Inherited Arrhythmias |
title_full |
Channelopathies - Emerging Trends in The Management of Inherited Arrhythmias |
title_fullStr |
Channelopathies - Emerging Trends in The Management of Inherited Arrhythmias |
title_full_unstemmed |
Channelopathies - Emerging Trends in The Management of Inherited Arrhythmias |
title_sort |
channelopathies - emerging trends in the management of inherited arrhythmias |
publisher |
Elsevier |
series |
Indian Pacing and Electrophysiology Journal |
issn |
0972-6292 |
publishDate |
2015-01-01 |
description |
In spite of their relative rarity, inheritable arrhythmias have come to the forefront as a group of potentially fatal but preventable cause of sudden cardiac death in children and (young) adults. Comprehensive management of inherited arrhythmias includes diagnosing and treating the proband and identifying and protecting affected family members. This has been made possible by the vast advances in the field of molecular biology enabling better understanding of the genetic underpinnings of some of these disease groups, namely congenital long QT syndrome, catecholaminergic polymorphic ventricular tachycardia and Brugada syndrome. The ensuing knowledge of the genotype-phenotype correlations enables us to risk-stratify, prognosticate and treat based on the genetic test results. The various diagnostic modalities currently available to us, including clinical tools and genetic technologies, have to be applied judiciously in order to promptly identify those affected and to spare the emotional burden of a potentially lethal disease in the unaffected individuals. The therapeutic armamentarium of inherited arrhythmias includes pharmacological agents, device therapies and surgical interventions. A treatment strategy keeping in mind the risk profile of the patients, the local availability of drugs and the expertise of the treating personnel is proving effective. While opportunities for research are numerous in this expanding field of medicine, there is also tremendous scope for incorporating the emerging trends in managing patients and families with inherited arrhythmias in the Indian subcontinent. |
topic |
Channelopathies Inherited Arrhythmias |
url |
http://www.sciencedirect.com/science/article/pii/S0972629216308415 |
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