Recent Trends in Microextraction Techniques Employed in Analytical and Bioanalytical Sample Preparation
Sample preparation has been recognized as a major step in the chemical analysis workflow. As such, substantial efforts have been made in recent years to simplify the overall sample preparation process. Major focusses of these efforts have included miniaturization of the extraction device; minimizing...
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doaj-77b2d824f8c841dc8a3a89aecb4087e12020-11-25T01:41:50ZengMDPI AGSeparations2297-87392017-12-01443610.3390/separations4040036separations4040036Recent Trends in Microextraction Techniques Employed in Analytical and Bioanalytical Sample PreparationAbuzar Kabir0Marcello Locatelli1Halil Ibrahim Ulusoy2International Forensic Research Institute, Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th St, Miami, FL 33199, USADepartment of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Analytical Chemistry, Faculty of Pharmacy, Cumhuriyet University, 58140 Sivas, TurkeySample preparation has been recognized as a major step in the chemical analysis workflow. As such, substantial efforts have been made in recent years to simplify the overall sample preparation process. Major focusses of these efforts have included miniaturization of the extraction device; minimizing/eliminating toxic and hazardous organic solvent consumption; eliminating sample pre-treatment and post-treatment steps; reducing the sample volume requirement; reducing extraction equilibrium time, maximizing extraction efficiency etc. All these improved attributes are congruent with the Green Analytical Chemistry (GAC) principles. Classical sample preparation techniques such as solid phase extraction (SPE) and liquid-liquid extraction (LLE) are being rapidly replaced with emerging miniaturized and environmentally friendly techniques such as Solid Phase Micro Extraction (SPME), Stir bar Sorptive Extraction (SBSE), Micro Extraction by Packed Sorbent (MEPS), Fabric Phase Sorptive Extraction (FPSE), and Dispersive Liquid-Liquid Micro Extraction (DLLME). In addition to the development of many new generic extraction sorbents in recent years, a large number of molecularly imprinted polymers (MIPs) created using different template molecules have also enriched the large cache of microextraction sorbents. Application of nanoparticles as high-performance extraction sorbents has undoubtedly elevated the extraction efficiency and method sensitivity of modern chromatographic analyses to a new level. Combining magnetic nanoparticles with many microextraction sorbents has opened up new possibilities to extract target analytes from sample matrices containing high volumes of matrix interferents. The aim of the current review is to critically audit the progress of microextraction techniques in recent years, which has indisputably transformed the analytical chemistry practices, from biological and therapeutic drug monitoring to the environmental field; from foods to phyto-pharmaceutical applications.https://www.mdpi.com/2297-8739/4/4/36MEPSFPSEDLLMEmagnetic nanoparticlesMIPextraction proceduresgreen analytical chemistryquantitative analyses |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abuzar Kabir Marcello Locatelli Halil Ibrahim Ulusoy |
spellingShingle |
Abuzar Kabir Marcello Locatelli Halil Ibrahim Ulusoy Recent Trends in Microextraction Techniques Employed in Analytical and Bioanalytical Sample Preparation Separations MEPS FPSE DLLME magnetic nanoparticles MIP extraction procedures green analytical chemistry quantitative analyses |
author_facet |
Abuzar Kabir Marcello Locatelli Halil Ibrahim Ulusoy |
author_sort |
Abuzar Kabir |
title |
Recent Trends in Microextraction Techniques Employed in Analytical and Bioanalytical Sample Preparation |
title_short |
Recent Trends in Microextraction Techniques Employed in Analytical and Bioanalytical Sample Preparation |
title_full |
Recent Trends in Microextraction Techniques Employed in Analytical and Bioanalytical Sample Preparation |
title_fullStr |
Recent Trends in Microextraction Techniques Employed in Analytical and Bioanalytical Sample Preparation |
title_full_unstemmed |
Recent Trends in Microextraction Techniques Employed in Analytical and Bioanalytical Sample Preparation |
title_sort |
recent trends in microextraction techniques employed in analytical and bioanalytical sample preparation |
publisher |
MDPI AG |
series |
Separations |
issn |
2297-8739 |
publishDate |
2017-12-01 |
description |
Sample preparation has been recognized as a major step in the chemical analysis workflow. As such, substantial efforts have been made in recent years to simplify the overall sample preparation process. Major focusses of these efforts have included miniaturization of the extraction device; minimizing/eliminating toxic and hazardous organic solvent consumption; eliminating sample pre-treatment and post-treatment steps; reducing the sample volume requirement; reducing extraction equilibrium time, maximizing extraction efficiency etc. All these improved attributes are congruent with the Green Analytical Chemistry (GAC) principles. Classical sample preparation techniques such as solid phase extraction (SPE) and liquid-liquid extraction (LLE) are being rapidly replaced with emerging miniaturized and environmentally friendly techniques such as Solid Phase Micro Extraction (SPME), Stir bar Sorptive Extraction (SBSE), Micro Extraction by Packed Sorbent (MEPS), Fabric Phase Sorptive Extraction (FPSE), and Dispersive Liquid-Liquid Micro Extraction (DLLME). In addition to the development of many new generic extraction sorbents in recent years, a large number of molecularly imprinted polymers (MIPs) created using different template molecules have also enriched the large cache of microextraction sorbents. Application of nanoparticles as high-performance extraction sorbents has undoubtedly elevated the extraction efficiency and method sensitivity of modern chromatographic analyses to a new level. Combining magnetic nanoparticles with many microextraction sorbents has opened up new possibilities to extract target analytes from sample matrices containing high volumes of matrix interferents. The aim of the current review is to critically audit the progress of microextraction techniques in recent years, which has indisputably transformed the analytical chemistry practices, from biological and therapeutic drug monitoring to the environmental field; from foods to phyto-pharmaceutical applications. |
topic |
MEPS FPSE DLLME magnetic nanoparticles MIP extraction procedures green analytical chemistry quantitative analyses |
url |
https://www.mdpi.com/2297-8739/4/4/36 |
work_keys_str_mv |
AT abuzarkabir recenttrendsinmicroextractiontechniquesemployedinanalyticalandbioanalyticalsamplepreparation AT marcellolocatelli recenttrendsinmicroextractiontechniquesemployedinanalyticalandbioanalyticalsamplepreparation AT halilibrahimulusoy recenttrendsinmicroextractiontechniquesemployedinanalyticalandbioanalyticalsamplepreparation |
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